Efficient one-step synthesis of 3-nitroflavones via cascade nitration-cyclization

Yilin Yang; Chukai Shao; Ruirui Hua; Rui Tian; Ziang Wang; Hongquan Yin; Houhua Zhu; Fu Xue Chen

doi:10.1039/d6ob00238b

Efficient one-step synthesis of 3-nitroflavones via cascade nitration-cyclization

Yilin Yang
, Chukai Shao^*
, Ruirui Hua
, Rui Tian
, Ziang Wang
, Hongquan Yin
, Houhua Zhu
, Fu Xue Chen^*

^*此作品的通讯作者

化学与化工学院

科研成果: 期刊稿件 › 文章 › 同行评审

摘要

A mild and regioselective nitration–cyclization of alkynyl aryl ketones has been developed to access 3-nitroflavones promoted by Zn(OTf)₂. Tandem nitration and intramolecular cyclization is achieved using 68% HNO₃ under room-temperature conditions, delivering substituted 3-nitroflavones in generally good to excellent yields.

源语言	英语
期刊	Organic and Biomolecular Chemistry
DOI	https://doi.org/10.1039/d6ob00238b
出版状态	已接受/待刊 - 2026

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10.1039/d6ob00238b

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title = "Efficient one-step synthesis of 3-nitroflavones via cascade nitration-cyclization",

abstract = "A mild and regioselective nitration–cyclization of alkynyl aryl ketones has been developed to access 3-nitroflavones promoted by Zn(OTf)2. Tandem nitration and intramolecular cyclization is achieved using 68\% HNO3 under room-temperature conditions, delivering substituted 3-nitroflavones in generally good to excellent yields.",

author = "Yilin Yang and Chukai Shao and Ruirui Hua and Rui Tian and Ziang Wang and Hongquan Yin and Houhua Zhu and Chen, \{Fu Xue\}",

note = "Publisher Copyright: This journal is {\textcopyright} The Royal Society of Chemistry, 2026",

year = "2026",

doi = "10.1039/d6ob00238b",

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journal = "Organic and Biomolecular Chemistry",

issn = "1477-0520",

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TY - JOUR

T1 - Efficient one-step synthesis of 3-nitroflavones via cascade nitration-cyclization

AU - Yang, Yilin

AU - Shao, Chukai

AU - Hua, Ruirui

AU - Tian, Rui

AU - Wang, Ziang

AU - Yin, Hongquan

AU - Zhu, Houhua

AU - Chen, Fu Xue

PY - 2026

Y1 - 2026

N2 - A mild and regioselective nitration–cyclization of alkynyl aryl ketones has been developed to access 3-nitroflavones promoted by Zn(OTf)2. Tandem nitration and intramolecular cyclization is achieved using 68% HNO3 under room-temperature conditions, delivering substituted 3-nitroflavones in generally good to excellent yields.

AB - A mild and regioselective nitration–cyclization of alkynyl aryl ketones has been developed to access 3-nitroflavones promoted by Zn(OTf)2. Tandem nitration and intramolecular cyclization is achieved using 68% HNO3 under room-temperature conditions, delivering substituted 3-nitroflavones in generally good to excellent yields.

UR - https://www.scopus.com/pages/publications/105033070915

U2 - 10.1039/d6ob00238b

DO - 10.1039/d6ob00238b

M3 - Article

AN - SCOPUS:105033070915

SN - 1477-0520

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

ER -

Efficient one-step synthesis of 3-nitroflavones via cascade nitration-cyclization

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