Dual responsive supramolecular nanogels for intracellular drug delivery

Xiaofei Chen; Li Chen; Xuemei Yao; Zhe Zhang; Chaoliang He; Jingping Zhang; Xuesi Chen

doi:10.1039/c4cc00016a

Dual responsive supramolecular nanogels for intracellular drug delivery

Xiaofei Chen
, Li Chen^*
, Xuemei Yao
, Zhe Zhang
, Chaoliang He
, Jingping Zhang
, Xuesi Chen

^*此作品的通讯作者

Northeast Normal University
CAS - Changchun Institute of Applied Chemistry

科研成果: 期刊稿件 › 文章 › 同行评审

78 引用（Scopus）

摘要

Supramolecular nanogels cross-linked by host–guest interaction between dextran grafted benzimidazole (Dex-g-BM) and thiol-β-cyclodextrin were designed. Their special supramolecular pH-sensitivity under acidic conditions (pH < 6, within the range of malignant cellular endosomes) and reduction sensitivity in response to biologically relevant stimuli will be of great advantage to the future of cancer chemotherapeutics.

源语言	英语
页（从-至）	3789-3791
页数	3
期刊	Chemical Communications
卷	50
期	29
DOI	https://doi.org/10.1039/c4cc00016a
出版状态	已出版 - 13 3月 2014
已对外发布	是

联合国可持续发展目标

此成果有助于实现下列可持续发展目标：

可持续发展目标 3 良好健康与福祉

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引用此

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author = "Xiaofei Chen and Li Chen and Xuemei Yao and Zhe Zhang and Chaoliang He and Jingping Zhang and Xuesi Chen",

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T1 - Dual responsive supramolecular nanogels for intracellular drug delivery

AU - Chen, Xiaofei

AU - Chen, Li

AU - Yao, Xuemei

AU - Zhang, Zhe

AU - He, Chaoliang

AU - Zhang, Jingping

AU - Chen, Xuesi

PY - 2014/3/13

Y1 - 2014/3/13

N2 - Supramolecular nanogels cross-linked by host–guest interaction between dextran grafted benzimidazole (Dex-g-BM) and thiol-β-cyclodextrin were designed. Their special supramolecular pH-sensitivity under acidic conditions (pH < 6, within the range of malignant cellular endosomes) and reduction sensitivity in response to biologically relevant stimuli will be of great advantage to the future of cancer chemotherapeutics.

AB - Supramolecular nanogels cross-linked by host–guest interaction between dextran grafted benzimidazole (Dex-g-BM) and thiol-β-cyclodextrin were designed. Their special supramolecular pH-sensitivity under acidic conditions (pH < 6, within the range of malignant cellular endosomes) and reduction sensitivity in response to biologically relevant stimuli will be of great advantage to the future of cancer chemotherapeutics.

UR - https://www.scopus.com/pages/publications/84896281552

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DO - 10.1039/c4cc00016a

M3 - Article

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Dual responsive supramolecular nanogels for intracellular drug delivery

摘要

联合国可持续发展目标

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