Distribution and accumulation of caffeine in rat tissues and its inhibition on semicarbazide-sensitive amine oxidase

Baoquan Che; Lin Wang; Zhe Zhang; Yongqian Zhang; Yulin Deng

doi:10.1016/j.neuro.2012.07.004

Distribution and accumulation of caffeine in rat tissues and its inhibition on semicarbazide-sensitive amine oxidase

Baoquan Che
, Lin Wang
, Zhe Zhang
, Yongqian Zhang
, Yulin Deng^*

^*此作品的通讯作者

医学科学与工程学院

Beijing Institute of Technology
Beijing Institute for Drug Control

科研成果: 期刊稿件 › 文章 › 同行评审

20 引用（Scopus）

摘要

Wistar rats were treated with caffeine or 2-bromoethylamine, the effect of caffeine on the activity of semicarbazide-sensitive amine oxidase (SSAO) in rat serum and tissues was studied using various LC-MS methods. Caffeine was found to present in all tissues after administration for 10 days and accumulated for 25 days. The level of caffeine was high in brain and liver, and the SSAO activity in all tissues was found to be inhibited by caffeine. As the concentration of caffeine increased, the SSAO activity decreased. The inhibition ratio was correlated to the levels of caffeine present. We presume that caffeine may treat with SSAO activity associated diseases.

源语言	英语
页（从-至）	1248-1253
页数	6
期刊	NeuroToxicology
卷	33
期	5
DOI	https://doi.org/10.1016/j.neuro.2012.07.004
出版状态	已出版 - 10月 2012

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title = "Distribution and accumulation of caffeine in rat tissues and its inhibition on semicarbazide-sensitive amine oxidase",

abstract = "Wistar rats were treated with caffeine or 2-bromoethylamine, the effect of caffeine on the activity of semicarbazide-sensitive amine oxidase (SSAO) in rat serum and tissues was studied using various LC-MS methods. Caffeine was found to present in all tissues after administration for 10 days and accumulated for 25 days. The level of caffeine was high in brain and liver, and the SSAO activity in all tissues was found to be inhibited by caffeine. As the concentration of caffeine increased, the SSAO activity decreased. The inhibition ratio was correlated to the levels of caffeine present. We presume that caffeine may treat with SSAO activity associated diseases.",

keywords = "Accumulation, Caffeine, Distribution, Inhibitor, SSAO",

author = "Baoquan Che and Lin Wang and Zhe Zhang and Yongqian Zhang and Yulin Deng",

year = "2012",

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doi = "10.1016/j.neuro.2012.07.004",

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T1 - Distribution and accumulation of caffeine in rat tissues and its inhibition on semicarbazide-sensitive amine oxidase

AU - Che, Baoquan

AU - Wang, Lin

AU - Zhang, Zhe

AU - Zhang, Yongqian

AU - Deng, Yulin

PY - 2012/10

Y1 - 2012/10

N2 - Wistar rats were treated with caffeine or 2-bromoethylamine, the effect of caffeine on the activity of semicarbazide-sensitive amine oxidase (SSAO) in rat serum and tissues was studied using various LC-MS methods. Caffeine was found to present in all tissues after administration for 10 days and accumulated for 25 days. The level of caffeine was high in brain and liver, and the SSAO activity in all tissues was found to be inhibited by caffeine. As the concentration of caffeine increased, the SSAO activity decreased. The inhibition ratio was correlated to the levels of caffeine present. We presume that caffeine may treat with SSAO activity associated diseases.

AB - Wistar rats were treated with caffeine or 2-bromoethylamine, the effect of caffeine on the activity of semicarbazide-sensitive amine oxidase (SSAO) in rat serum and tissues was studied using various LC-MS methods. Caffeine was found to present in all tissues after administration for 10 days and accumulated for 25 days. The level of caffeine was high in brain and liver, and the SSAO activity in all tissues was found to be inhibited by caffeine. As the concentration of caffeine increased, the SSAO activity decreased. The inhibition ratio was correlated to the levels of caffeine present. We presume that caffeine may treat with SSAO activity associated diseases.

KW - Accumulation

KW - Caffeine

KW - Distribution

KW - Inhibitor

KW - SSAO

UR - https://www.scopus.com/pages/publications/84867233411

U2 - 10.1016/j.neuro.2012.07.004

DO - 10.1016/j.neuro.2012.07.004

M3 - Article

C2 - 22841599

AN - SCOPUS:84867233411

SN - 0161-813X

VL - 33

SP - 1248

EP - 1253

JO - NeuroToxicology

JF - NeuroToxicology

IS - 5

ER -

Distribution and accumulation of caffeine in rat tissues and its inhibition on semicarbazide-sensitive amine oxidase

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