Development and characterizations of a miniature capillary electrophoresis mass spectrometry system

Muyi He; Zhenhua Xue; Yinna Zhang; Zejian Huang; Xiang Fang; Feng Qu; Zheng Ouyang; Wei Xu

doi:10.1021/ac504868w

Development and characterizations of a miniature capillary electrophoresis mass spectrometry system

Muyi He
, Zhenhua Xue
, Yinna Zhang
, Zejian Huang
, Xiang Fang
, Feng Qu
, Zheng Ouyang
, Wei Xu^*

^*此作品的通讯作者

医学科学与工程学院

Beijing Institute of Technology
National Institute of Metrology China
Purdue University

科研成果: 期刊稿件 › 文章 › 同行评审

46 引用（Scopus）

摘要

A miniature capillary electrophoresis mass spectrometry (CE/MS) system has been developed in this work. A 100% electrical driven miniaturized CE device was integrated with a miniature MS instrument, which has a discontinuous atmospheric pressure interface (DAPI) for coupling with atmospheric pressure ionization sources. A nanoelectrospray ionization (nano-ESI) source was developed with a sheath liquid interface for coupling the miniature CE and the MS system. A systematic characterization and optimization of the analytical performance have been done. The analysis of isobaric peptides and avoiding charge competition effects in nano-ESI sources have been demonstrated.

源语言	英语
页（从-至）	2236-2241
页数	6
期刊	Analytical Chemistry
卷	87
期	4
DOI	https://doi.org/10.1021/ac504868w
出版状态	已出版 - 17 2月 2015

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abstract = "A miniature capillary electrophoresis mass spectrometry (CE/MS) system has been developed in this work. A 100\% electrical driven miniaturized CE device was integrated with a miniature MS instrument, which has a discontinuous atmospheric pressure interface (DAPI) for coupling with atmospheric pressure ionization sources. A nanoelectrospray ionization (nano-ESI) source was developed with a sheath liquid interface for coupling the miniature CE and the MS system. A systematic characterization and optimization of the analytical performance have been done. The analysis of isobaric peptides and avoiding charge competition effects in nano-ESI sources have been demonstrated.",

author = "Muyi He and Zhenhua Xue and Yinna Zhang and Zejian Huang and Xiang Fang and Feng Qu and Zheng Ouyang and Wei Xu",

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AU - He, Muyi

AU - Xue, Zhenhua

AU - Zhang, Yinna

AU - Huang, Zejian

AU - Fang, Xiang

AU - Qu, Feng

AU - Ouyang, Zheng

AU - Xu, Wei

PY - 2015/2/17

Y1 - 2015/2/17

N2 - A miniature capillary electrophoresis mass spectrometry (CE/MS) system has been developed in this work. A 100% electrical driven miniaturized CE device was integrated with a miniature MS instrument, which has a discontinuous atmospheric pressure interface (DAPI) for coupling with atmospheric pressure ionization sources. A nanoelectrospray ionization (nano-ESI) source was developed with a sheath liquid interface for coupling the miniature CE and the MS system. A systematic characterization and optimization of the analytical performance have been done. The analysis of isobaric peptides and avoiding charge competition effects in nano-ESI sources have been demonstrated.

AB - A miniature capillary electrophoresis mass spectrometry (CE/MS) system has been developed in this work. A 100% electrical driven miniaturized CE device was integrated with a miniature MS instrument, which has a discontinuous atmospheric pressure interface (DAPI) for coupling with atmospheric pressure ionization sources. A nanoelectrospray ionization (nano-ESI) source was developed with a sheath liquid interface for coupling the miniature CE and the MS system. A systematic characterization and optimization of the analytical performance have been done. The analysis of isobaric peptides and avoiding charge competition effects in nano-ESI sources have been demonstrated.

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JO - Analytical Chemistry

JF - Analytical Chemistry

IS - 4

ER -

Development and characterizations of a miniature capillary electrophoresis mass spectrometry system

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