Corrigendum to “Self-controlled in silico gene knockdown strategies to enhance the sustainable production of heterologous terpenoid by Saccharomyces cerevisiae” [Metab. Eng. 83 (2024) 172–182, (S1096717624000594), (10.1016/j.ymben.2024.04.005)]

The authors regret that. 1. On page 172, in the Abstract section, the text currently reads as “[The simulation predicted that the single deletion of fol1, fol2, fol3, abz1, and abz2, or a combined knockout of hfd1, ald2 and ald3 could improve its OA production.]” should be replaced with "[The simulation predicted that the single deletion of fol1, fol2, fol3, abz1, abz2 and pha2, or a combined knockout of hfd1, ald2 and ald3 could improve its OA production.]".2. On page 172, in the Abstract section, the text currently reads as “[Consequently, strains EK1∼EK7 were constructed and cultivated. EK3 (OA07△fol3), EK5 (OA07△abz1), and EK6 (OA07△abz2) had significantly higher OA titers in a batch cultivation compared to the original strain OA07.]” should be replaced with "[Consequently, strains EK1∼EK7 were constructed and cultivated. EK3 (OA07△fol3), EK5 (OA07△abz2), and EK6 (OA07△pha2) had significantly higher OA titers in a batch cultivation compared to the original strain OA07.]".3. On page 172, in the Abstract section, the text currently reads as “[To address this, we designed a negative feedback circuit regulated by malonyl-CoA, a growth-associated intermediate whose synthesis served as a bypass to OA synthesis, at fol3, abz1, abz2, and at acetyl-CoA carboxylase encoding gene acc1, to dynamically and autonomously regulate the expression of these genes in OA07.]” should be replaced with "[To address this, we designed a negative feedback circuit regulated by malonyl-CoA, a growth-associated intermediate whose synthesis served as a bypass to OA synthesis, at fol3, abz2, pha2, and at acetyl-CoA carboxylase encoding gene acc1, to dynamically and autonomously regulate the expression of these genes in OA07.]".4. On page 179, in the Discussion section, the text currently reads as “[Herein, the rigid deletion of gene targets (fol3, abz1, and abz2) predicted via the OptKnock framework was replaced by the corresponding gene suppression associated with the native metabolism (Fig. S2).]” should be replaced with "[Herein, the rigid deletion of gene targets (fol3, abz2, and pha2) predicted via the OptKnock framework was replaced by the corresponding gene suppression associated with the native metabolism (Fig. S2).]".5. On page 179, in the Discussion section, the text currently reads as “[In details, the mechanism that malonyl-CoA enacts the conformational change of the transcription repressor FapR and thus detaches it from the cis-regulatory element fapO was applied to develop malonyl-CoA activated antisense transcription on fol3, abz1, and abz2, respectively, as well as acc1.]” should be replaced with "[In details, the mechanism that malonyl-CoA enacts the conformational change of the transcription repressor FapR and thus detaches it from the cis-regulatory element fapO was applied to develop malonyl-CoA activated antisense transcription on fol3, abz2, and pha2, respectively, as well as acc1.]".The authors would like to apologise for any inconvenience caused.