Copper-Catalyzed Remote C5-Selective Chlorination of 8-Amidoquinolines Using Sulfonyl Chlorides as Cl Source

Han Zhang, Miao Xu, Ningning Liu, Fanzhi Yang*

*此作品的通讯作者

科研成果: 期刊稿件文章同行评审

4 引用 (Scopus)

摘要

Sulfonyl chloride has been rarely used as Cl source in transition metal-catalyzed C−H functionalizations. We report the unprecedented copper-catalyzed remote C5-chlorination of substituted 8-amidoquinolines with sulfonyl chloride under 1 atm oxygen. 10 sulfonyl chlorides and 15 substituted 8-amidoquinolines were tested, generating moderate to high yields. The catalytic system showed high regio-selectivity, as well as good functional group tolerance.

源语言英语
页(从-至)2319-2322
页数4
期刊ChemistrySelect
6
9
DOI
出版状态已出版 - 5 3月 2021

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