Chiral iridium catalysts bearing spiro pyridine-aminophosphine ligands enable highly efficient asymmetric hydrogenation of β-aryl β-ketoesters

Jian Hua Xie; Xiao Yan Liu; Xiao Hui Yang; Jian Bo Xie; Li Xin Wang; Qi Lin Zhou

doi:10.1002/anie.201105780

Chiral iridium catalysts bearing spiro pyridine-aminophosphine ligands enable highly efficient asymmetric hydrogenation of β-aryl β-ketoesters

Jian Hua Xie^*
, Xiao Yan Liu
, Xiao Hui Yang
, Jian Bo Xie
, Li Xin Wang
, Qi Lin Zhou

^*此作品的通讯作者

Nankai University

科研成果: 期刊稿件 › 文章 › 同行评审

141 引用（Scopus）

摘要

Tons of TONs: Chiral iridium catalysts bearing ligand 1 are highly efficient for the asymmetric hydrogenation of β-substituted β-ketoesters. The product β-hydroxyesters are delivered in high yield with excellent enantioselectivities and high turnover numbers (TONs). cod= 1,5-cyclooctadiene.

源语言	英语
页（从-至）	201-203
页数	3
期刊	Angewandte Chemie - International Edition
卷	51
期	1
DOI	https://doi.org/10.1002/anie.201105780
出版状态	已出版 - 2 1月 2012
已对外发布	是

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title = "Chiral iridium catalysts bearing spiro pyridine-aminophosphine ligands enable highly efficient asymmetric hydrogenation of β-aryl β-ketoesters",

abstract = "Tons of TONs: Chiral iridium catalysts bearing ligand 1 are highly efficient for the asymmetric hydrogenation of β-substituted β-ketoesters. The product β-hydroxyesters are delivered in high yield with excellent enantioselectivities and high turnover numbers (TONs). cod= 1,5-cyclooctadiene.",

keywords = "enantioselectivity, hydrogenation, iridium, ligand effects, synthetic methods",

author = "Xie, \{Jian Hua\} and Liu, \{Xiao Yan\} and Yang, \{Xiao Hui\} and Xie, \{Jian Bo\} and Wang, \{Li Xin\} and Zhou, \{Qi Lin\}",

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AU - Xie, Jian Hua

AU - Liu, Xiao Yan

AU - Yang, Xiao Hui

AU - Xie, Jian Bo

AU - Wang, Li Xin

AU - Zhou, Qi Lin

PY - 2012/1/2

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N2 - Tons of TONs: Chiral iridium catalysts bearing ligand 1 are highly efficient for the asymmetric hydrogenation of β-substituted β-ketoesters. The product β-hydroxyesters are delivered in high yield with excellent enantioselectivities and high turnover numbers (TONs). cod= 1,5-cyclooctadiene.

AB - Tons of TONs: Chiral iridium catalysts bearing ligand 1 are highly efficient for the asymmetric hydrogenation of β-substituted β-ketoesters. The product β-hydroxyesters are delivered in high yield with excellent enantioselectivities and high turnover numbers (TONs). cod= 1,5-cyclooctadiene.

KW - enantioselectivity

KW - hydrogenation

KW - iridium

KW - ligand effects

KW - synthetic methods

UR - https://www.scopus.com/pages/publications/84855264047

U2 - 10.1002/anie.201105780

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Chiral iridium catalysts bearing spiro pyridine-aminophosphine ligands enable highly efficient asymmetric hydrogenation of β-aryl β-ketoesters

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