Characterization of hydroxypropyl methylcellulose acetate succinate

Zi Qiang Shao; Yi Ping Zheng; Yong Hong Li; Wen Jun Wang

Characterization of hydroxypropyl methylcellulose acetate succinate

Zi Qiang Shao^*
, Yi Ping Zheng
, Yong Hong Li
, Wen Jun Wang

^*此作品的通讯作者

材料学院

Beijing Institute of Technology

科研成果: 期刊稿件 › 文章 › 同行评审

2 引用（Scopus）

摘要

OBJECTIVE: To synthesize and analyze the novel enteric-coating material HPMCAS. METHODS: The structure and properties of HPMCAS were analyzed by IR, UV, TGA and chemical analysis. The solubility of HPMCAS in organic solvents was tested. The viscosity curves in the acetone-ethanol-water system, tensile strength and ultimate elongation of free films prepared by HPMCAS were determined, and HPMCAS was compared with AS-LG. RESULTS: The contents of acidic succinyl groups and acetyl groups in HPMCAS were related with the addition of two anhydrides. The dichloromethane-ethanol system was the excellent solvent for HPMCAS. HPMCAS was stable below 200 T and lose weight quickly over 200 °C. CONCLUSION: The physical and chemical properties of HPMCAS were almost the same as those of AS-LG.

源语言	英语
页（从-至）	846-849
页数	4
期刊	Chinese Pharmaceutical Journal
卷	40
期	11
出版状态	已出版 - 6月 2005

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title = "Characterization of hydroxypropyl methylcellulose acetate succinate",

abstract = "OBJECTIVE: To synthesize and analyze the novel enteric-coating material HPMCAS. METHODS: The structure and properties of HPMCAS were analyzed by IR, UV, TGA and chemical analysis. The solubility of HPMCAS in organic solvents was tested. The viscosity curves in the acetone-ethanol-water system, tensile strength and ultimate elongation of free films prepared by HPMCAS were determined, and HPMCAS was compared with AS-LG. RESULTS: The contents of acidic succinyl groups and acetyl groups in HPMCAS were related with the addition of two anhydrides. The dichloromethane-ethanol system was the excellent solvent for HPMCAS. HPMCAS was stable below 200 T and lose weight quickly over 200 °C. CONCLUSION: The physical and chemical properties of HPMCAS were almost the same as those of AS-LG.",

keywords = "Characterization, Enteric-coating material, Hydroxypropyl methylcellulose acetate succinate(HPMCAS), Properties, Structure",

author = "Shao, \{Zi Qiang\} and Zheng, \{Yi Ping\} and Li, \{Yong Hong\} and Wang, \{Wen Jun\}",

year = "2005",

month = jun,

language = "English",

volume = "40",

pages = "846--849",

journal = "Chinese Pharmaceutical Journal",

issn = "1001-2494",

publisher = "Chinese Pharmaceutical Association",

number = "11",

}

TY - JOUR

T1 - Characterization of hydroxypropyl methylcellulose acetate succinate

AU - Shao, Zi Qiang

AU - Zheng, Yi Ping

AU - Li, Yong Hong

AU - Wang, Wen Jun

PY - 2005/6

Y1 - 2005/6

N2 - OBJECTIVE: To synthesize and analyze the novel enteric-coating material HPMCAS. METHODS: The structure and properties of HPMCAS were analyzed by IR, UV, TGA and chemical analysis. The solubility of HPMCAS in organic solvents was tested. The viscosity curves in the acetone-ethanol-water system, tensile strength and ultimate elongation of free films prepared by HPMCAS were determined, and HPMCAS was compared with AS-LG. RESULTS: The contents of acidic succinyl groups and acetyl groups in HPMCAS were related with the addition of two anhydrides. The dichloromethane-ethanol system was the excellent solvent for HPMCAS. HPMCAS was stable below 200 T and lose weight quickly over 200 °C. CONCLUSION: The physical and chemical properties of HPMCAS were almost the same as those of AS-LG.

AB - OBJECTIVE: To synthesize and analyze the novel enteric-coating material HPMCAS. METHODS: The structure and properties of HPMCAS were analyzed by IR, UV, TGA and chemical analysis. The solubility of HPMCAS in organic solvents was tested. The viscosity curves in the acetone-ethanol-water system, tensile strength and ultimate elongation of free films prepared by HPMCAS were determined, and HPMCAS was compared with AS-LG. RESULTS: The contents of acidic succinyl groups and acetyl groups in HPMCAS were related with the addition of two anhydrides. The dichloromethane-ethanol system was the excellent solvent for HPMCAS. HPMCAS was stable below 200 T and lose weight quickly over 200 °C. CONCLUSION: The physical and chemical properties of HPMCAS were almost the same as those of AS-LG.

KW - Characterization

KW - Enteric-coating material

KW - Hydroxypropyl methylcellulose acetate succinate(HPMCAS)

KW - Properties

KW - Structure

UR - https://www.scopus.com/pages/publications/23644448903

M3 - Article

AN - SCOPUS:23644448903

SN - 1001-2494

VL - 40

SP - 846

EP - 849

JO - Chinese Pharmaceutical Journal

JF - Chinese Pharmaceutical Journal

IS - 11

ER -

Characterization of hydroxypropyl methylcellulose acetate succinate

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