TY - JOUR
T1 - Cascade Reaction-Mediated Assembly of Magnetic/Silver Nanoparticles for Amplified Magnetic Biosensing
AU - Chen, Yiping
AU - Xianyu, Yunlei
AU - Dong, Mingling
AU - Zhang, Jiangjiang
AU - Zheng, Wenshu
AU - Qian, Zhiyong
AU - Jiang, Xingyu
N1 - Publisher Copyright:
Copyright © 2018 American Chemical Society.
PY - 2018/6/5
Y1 - 2018/6/5
N2 - Conventional magnetic relaxation switching (MRS) sensor suffers from its relatively low sensitivity when it comes to the analysis of trace small molecules in complicated samples. To meet this challenge, we develop a cascade reaction-mediated magnetic relaxation switching (CR-MRS) sensor, based on the assembly of silver nanoparticles (Ag NPs) and magnetic nanoparticles (MNPs) to improve the sensitivity of conventional MRS. The cascade reaction triggered by alkaline phosphatase generates ascorbic acid, which reduces Ag+ to Ag NPs that can assemble the initially dispersed MNPs to form magnetic/silver nanoassemblies, thus modulating the state of MNPs to result in the change of transverse relaxation time. The formed magnetic/silver nanoassemblies can greatly enhance the state change of MNPs (from dispersed to aggregated) and dramatically improve the sensitivity of traditional MRS sensor, which makes this CR-MRS sensor a promising platform for highly sensitive detection of small molecules in complicated samples.
AB - Conventional magnetic relaxation switching (MRS) sensor suffers from its relatively low sensitivity when it comes to the analysis of trace small molecules in complicated samples. To meet this challenge, we develop a cascade reaction-mediated magnetic relaxation switching (CR-MRS) sensor, based on the assembly of silver nanoparticles (Ag NPs) and magnetic nanoparticles (MNPs) to improve the sensitivity of conventional MRS. The cascade reaction triggered by alkaline phosphatase generates ascorbic acid, which reduces Ag+ to Ag NPs that can assemble the initially dispersed MNPs to form magnetic/silver nanoassemblies, thus modulating the state of MNPs to result in the change of transverse relaxation time. The formed magnetic/silver nanoassemblies can greatly enhance the state change of MNPs (from dispersed to aggregated) and dramatically improve the sensitivity of traditional MRS sensor, which makes this CR-MRS sensor a promising platform for highly sensitive detection of small molecules in complicated samples.
UR - https://www.scopus.com/pages/publications/85046728734
U2 - 10.1021/acs.analchem.8b01138
DO - 10.1021/acs.analchem.8b01138
M3 - Article
C2 - 29727564
AN - SCOPUS:85046728734
SN - 0003-2700
VL - 90
SP - 6906
EP - 6912
JO - Analytical Chemistry
JF - Analytical Chemistry
IS - 11
ER -