Bridging biomechanics with neuropathological and neuroimaging insights for mTBI understanding through multiscale and multiphysics computational modeling

Mild traumatic brain injury (mTBI) represents a significant public health challenge in modern society. An in-depth analysis of the injury mechanisms, pathological forms, and assessment criteria of mTBI has underscored the pivotal role of craniocerebral models in comprehending and addressing mTBI. Research indicates that although existing finite element craniocerebral models have made strides in simulating the macroscopic biomechanical responses of the brain, they still fall short in accurately depicting the complexity of mTBI. Consequently, this paper emphasizes the necessity of integrating biomechanics, neuropathology, and neuroimaging to develop multiscale and multiphysics craniocerebral models, which are crucial for precisely capturing microscopic injuries, establishing pathological mechanical indicators, and simulating secondary and long-term brain functional impairments. The comprehensive analysis and in-depth discussion presented in this paper offer new perspectives and approaches for understanding, diagnosing, and preventing mTBI, potentially contributing to alleviating the global burden of mTBI.