Base-catalyzed one-pot tandem reaction: An effective strategy for the synthesis of pyrazolo[3,4-d]pyrimidinone derivatives

Ming Xing Liu; Jia Rong Li; Kai Zheng; Huan Yao; Qi Zhang; Da Xin Shi

doi:10.1016/j.tet.2015.07.065

Base-catalyzed one-pot tandem reaction: An effective strategy for the synthesis of pyrazolo[3,4-d]pyrimidinone derivatives

Ming Xing Liu
, Jia Rong Li
, Kai Zheng
, Huan Yao
, Qi Zhang
, Da Xin Shi^*

^*此作品的通讯作者

Beijing Institute of Technology

科研成果: 期刊稿件 › 文章 › 同行评审

12 引用（Scopus）

摘要

An effective one-pot multicomponent synthesis of pyrazolo[3,4-d]pyrimidinone derivatives through the tandem heterocyclization of hydrazine, methylenemalononitrile and aldehyde has been developed. This highly effective method includes nucleophilic addition, heterocyclization, substitution, intramolecular Pinner, Dimroth rearrangement and dehydroaromatization.

源语言	英语
期刊论文编号	27010
页（从-至）	7658-7662
页数	5
期刊	Tetrahedron
卷	71
期	40
DOI	https://doi.org/10.1016/j.tet.2015.07.065
出版状态	已出版 - 7 10月 2015
已对外发布	是

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title = "Base-catalyzed one-pot tandem reaction: An effective strategy for the synthesis of pyrazolo[3,4-d]pyrimidinone derivatives",

abstract = "An effective one-pot multicomponent synthesis of pyrazolo[3,4-d]pyrimidinone derivatives through the tandem heterocyclization of hydrazine, methylenemalononitrile and aldehyde has been developed. This highly effective method includes nucleophilic addition, heterocyclization, substitution, intramolecular Pinner, Dimroth rearrangement and dehydroaromatization.",

keywords = "Base catalysis, One-pot multicomponent heterocyclization, Pyrazolo[3,4-d]pyrimidinone",

author = "Liu, \{Ming Xing\} and Li, \{Jia Rong\} and Kai Zheng and Huan Yao and Qi Zhang and Shi, \{Da Xin\}",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier Ltd.",

year = "2015",

month = oct,

day = "7",

doi = "10.1016/j.tet.2015.07.065",

language = "English",

volume = "71",

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TY - JOUR

T1 - Base-catalyzed one-pot tandem reaction

T2 - An effective strategy for the synthesis of pyrazolo[3,4-d]pyrimidinone derivatives

AU - Liu, Ming Xing

AU - Li, Jia Rong

AU - Zheng, Kai

AU - Yao, Huan

AU - Zhang, Qi

AU - Shi, Da Xin

PY - 2015/10/7

Y1 - 2015/10/7

N2 - An effective one-pot multicomponent synthesis of pyrazolo[3,4-d]pyrimidinone derivatives through the tandem heterocyclization of hydrazine, methylenemalononitrile and aldehyde has been developed. This highly effective method includes nucleophilic addition, heterocyclization, substitution, intramolecular Pinner, Dimroth rearrangement and dehydroaromatization.

AB - An effective one-pot multicomponent synthesis of pyrazolo[3,4-d]pyrimidinone derivatives through the tandem heterocyclization of hydrazine, methylenemalononitrile and aldehyde has been developed. This highly effective method includes nucleophilic addition, heterocyclization, substitution, intramolecular Pinner, Dimroth rearrangement and dehydroaromatization.

KW - Base catalysis

KW - One-pot multicomponent heterocyclization

KW - Pyrazolo[3,4-d]pyrimidinone

UR - https://www.scopus.com/pages/publications/84940461885

U2 - 10.1016/j.tet.2015.07.065

DO - 10.1016/j.tet.2015.07.065

M3 - Article

AN - SCOPUS:84940461885

SN - 0040-4020

VL - 71

SP - 7658

EP - 7662

JO - Tetrahedron

JF - Tetrahedron

IS - 40

M1 - 27010

ER -

Base-catalyzed one-pot tandem reaction: An effective strategy for the synthesis of pyrazolo[3,4-d]pyrimidinone derivatives

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