@inproceedings{92a8eedd8d9f4d3dba6797a59deafaf4,
title = "Automated biomanipulation to assemble cellular microstructure with railed multi-microrobotic system",
abstract = "The fabrication of vessel-mimetic microchannel provides critical access to enable sufficient nutrient delivery for engineered composite tissues. This paper presents a novel method to engineer vascular-like microchannel by automated assembly of donut-shaped micromodules embedding fibroblast cells. A railed microrobotic system is set up with multi manipulators of 30 nm positioning resolution under an optical microscope. The coordinated manipulation among the micromanipulators is performed with newly designed concentric movement along the rail, which realized the arbitrary change of micromanipulator posture. With the novel developed image processing algorithm for the tracking of micromanipulator and micromodules, the automated bio-assembly of vascular-like microchannel is achieved which is free from the influence of the occlusion during contact manipulation. Experimental results showed that the pick-up success rate is around 98\% and tracking algorithm is robust. Finally, we achieved automated assembly of microchannel at a speed of 6 micromodules/min, which is efficient enough to fabricate vessel-mimetic substitute with macro-significance dimension for biological application.",
keywords = "Automated micromanipulation, bio-assembly, image processing, microrobotic, tissue engineering",
author = "Huaping Wang and Qing Shi and Qiang Huang and Tao Sun and Toshio Fukuda and Masahiro Nakajima and Masaru Takeuchi",
note = "Publisher Copyright: {\textcopyright} 2015 IEEE.; 2015 IEEE International Conference on Information and Automation, ICIA 2015 - In conjunction with 2015 IEEE International Conference on Automation and Logistics ; Conference date: 08-08-2015 Through 10-08-2015",
year = "2015",
month = sep,
day = "28",
doi = "10.1109/ICInfA.2015.7279383",
language = "English",
series = "2015 IEEE International Conference on Information and Automation, ICIA 2015 - In conjunction with 2015 IEEE International Conference on Automation and Logistics",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
pages = "743--748",
booktitle = "2015 IEEE International Conference on Information and Automation, ICIA 2015 - In conjunction with 2015 IEEE International Conference on Automation and Logistics",
address = "United States",
}