Atavistic strategy for the treatment of hyperuricemia via ionizable liposomal mRNA

Mengjie Zhang; Abid Hussain; Bo Hu; Haiyin Yang; Chunhui Li; Shuai Guo; Xiaofeng Han; Bei Li; Yunlu Dai; Yuhong Cao; Hang Chi; Yuhua Weng; Cheng Feng Qin; Yuanyu Huang

doi:10.1038/s41467-024-50752-9

Atavistic strategy for the treatment of hyperuricemia via ionizable liposomal mRNA

Mengjie Zhang
, Abid Hussain
, Bo Hu
, Haiyin Yang
, Chunhui Li
, Shuai Guo
, Xiaofeng Han
, Bei Li
, Yunlu Dai
, Yuhong Cao
, Hang Chi
, Yuhua Weng
, Cheng Feng Qin
, Yuanyu Huang^*

^*此作品的通讯作者

Beijing Institute of Technology
Rigerna Therapeutics
University of Macau
National Center for Nanoscience and Technology
Academy of Military Medical Science China

科研成果: 期刊稿件 › 文章 › 同行评审

35 引用（Scopus）

摘要

Urate oxidase (Uox) lost its function during evolution. Here the authors propose an atavistic strategy to treat hyperuricemia by using a proprietary lipid nanoparticle to load Uox mRNA, which reduced the serum uric acid levels effectively in two animal models.

源语言	英语
文章编号	6463
期刊	Nature Communications
卷	15
期	1
DOI	https://doi.org/10.1038/s41467-024-50752-9
出版状态	已出版 - 12月 2024
已对外发布	是

联合国可持续发展目标

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可持续发展目标 3 良好健康与福祉

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title = "Atavistic strategy for the treatment of hyperuricemia via ionizable liposomal mRNA",

abstract = "Urate oxidase (Uox) lost its function during evolution. Here the authors propose an atavistic strategy to treat hyperuricemia by using a proprietary lipid nanoparticle to load Uox mRNA, which reduced the serum uric acid levels effectively in two animal models.",

author = "Mengjie Zhang and Abid Hussain and Bo Hu and Haiyin Yang and Chunhui Li and Shuai Guo and Xiaofeng Han and Bei Li and Yunlu Dai and Yuhong Cao and Hang Chi and Yuhua Weng and Qin, \{Cheng Feng\} and Yuanyu Huang",

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doi = "10.1038/s41467-024-50752-9",

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AU - Zhang, Mengjie

AU - Hussain, Abid

AU - Hu, Bo

AU - Yang, Haiyin

AU - Li, Chunhui

AU - Guo, Shuai

AU - Han, Xiaofeng

AU - Li, Bei

AU - Dai, Yunlu

AU - Cao, Yuhong

AU - Chi, Hang

AU - Weng, Yuhua

AU - Qin, Cheng Feng

AU - Huang, Yuanyu

PY - 2024/12

Y1 - 2024/12

N2 - Urate oxidase (Uox) lost its function during evolution. Here the authors propose an atavistic strategy to treat hyperuricemia by using a proprietary lipid nanoparticle to load Uox mRNA, which reduced the serum uric acid levels effectively in two animal models.

AB - Urate oxidase (Uox) lost its function during evolution. Here the authors propose an atavistic strategy to treat hyperuricemia by using a proprietary lipid nanoparticle to load Uox mRNA, which reduced the serum uric acid levels effectively in two animal models.

UR - https://www.scopus.com/pages/publications/85200299943

U2 - 10.1038/s41467-024-50752-9

DO - 10.1038/s41467-024-50752-9

M3 - Article

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AN - SCOPUS:85200299943

SN - 2041-1723

VL - 15

JO - Nature Communications

JF - Nature Communications

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ER -

Atavistic strategy for the treatment of hyperuricemia via ionizable liposomal mRNA

摘要

联合国可持续发展目标

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