Asymmetric Transfer Hydrogenation of Trifluoromethylated Imines to Chiral α-Trifluoromethylated Amines With Alcohol as The Hydrogen Source

An efficient Pd/Zn co-catalyzed method for the asymmetric transfer hydrogenation of trifluoromethylated imines to chiral α-trifluoromethylated amines using methanol as the hydrogen source has been developed. The reaction showed good substrate scope and the products were obtained in excellent yields (up to 99%) with excellent enantioselectivity. The present methodology was compatible for the synthesis of deuterated chiral α-trifluoromethylated amines. On using CD₃OD as the deuterium source, deuterium incorporation up to 98% was observed without compromising the reaction outcome.