An Integrated Digital Microfluidic Platform with Functional Micropillar Arrays and Miniature Mass Spectrometry for Exosome Isolation and Molecular Fingerprinting

Menglei Zhao; Liyuan Guo; Gong Li; Haobing Liu; Rongxin Fu; Kangfu Chen; Hang Li; Shuailong Zhang

doi:10.1109/MEMS64181.2026.11419330

An Integrated Digital Microfluidic Platform with Functional Micropillar Arrays and Miniature Mass Spectrometry for Exosome Isolation and Molecular Fingerprinting

Menglei Zhao
, Liyuan Guo
, Gong Li
, Haobing Liu
, Rongxin Fu
, Kangfu Chen
, Hang Li^*
, Shuailong Zhang^*

^*此作品的通讯作者

Beijing Institute of Technology

科研成果: 书/报告/会议事项章节 › 会议稿件 › 同行评审

摘要

This paper presents an innovative digital microfluidic (DMF) platform that integrates functionalized micropillar arrays with a miniature mass spectrometer (mini-MS), offering a powerful and efficient system for exosome enrichment and analysis. The platform facilitates rapid and automated exosome isolation from ultratrace biological samples (1 μ L), achieving a 96% recovery rate within 20 minutes, while preserving exosome activity. Furthermore, the system enables direct molecular fingerprinting without the need for complex sample preparation or extraction processes, thereby minimizing contamination risks and sample loss. Using this approach, we successfully identified potential pancreatic cancer biomarkers, including lactate, LPC(18:1), and PC(34:1), from the enriched exosomes, demonstrating the platform's significant potential for both diagnostic and therapeutic applications in cancer research.

源语言	英语
主期刊名	2026 IEEE 39th International Conference on Micro Electro Mechanical Systems, MEMS 2026
出版商	Institute of Electrical and Electronics Engineers Inc.
页	167-170
页数	4
ISBN（电子版）	9798331572518
DOI	https://doi.org/10.1109/MEMS64181.2026.11419330
出版状态	已出版 - 2026
活动	39th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2026 - Salzburg, 奥地利期限: 25 1月 2026 → 29 1月 2026

丛书

姓名	Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
ISSN（印刷版）	1084-6999

会议

会议	39th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2026
国家/地区	奥地利
市	Salzburg
时期	25/01/26 → 29/01/26

访问文件

10.1109/MEMS64181.2026.11419330

其它文件与链接

链接到 Scopus 的出版物

引用此

Zhao, M., Guo, L., Li, G., Liu, H., Fu, R., Chen, K., Li, H., & Zhang, S. (2026). An Integrated Digital Microfluidic Platform with Functional Micropillar Arrays and Miniature Mass Spectrometry for Exosome Isolation and Molecular Fingerprinting. 在 2026 IEEE 39th International Conference on Micro Electro Mechanical Systems, MEMS 2026 (页码 167-170). (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/MEMS64181.2026.11419330

Zhao, Menglei ; Guo, Liyuan ; Li, Gong 等. / An Integrated Digital Microfluidic Platform with Functional Micropillar Arrays and Miniature Mass Spectrometry for Exosome Isolation and Molecular Fingerprinting. 2026 IEEE 39th International Conference on Micro Electro Mechanical Systems, MEMS 2026. Institute of Electrical and Electronics Engineers Inc., 2026. 页码 167-170 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)).

@inproceedings{81d5c59d241e4a13b95cd3df6340851a,

title = "An Integrated Digital Microfluidic Platform with Functional Micropillar Arrays and Miniature Mass Spectrometry for Exosome Isolation and Molecular Fingerprinting",

abstract = "This paper presents an innovative digital microfluidic (DMF) platform that integrates functionalized micropillar arrays with a miniature mass spectrometer (mini-MS), offering a powerful and efficient system for exosome enrichment and analysis. The platform facilitates rapid and automated exosome isolation from ultratrace biological samples (1 μ L), achieving a 96\% recovery rate within 20 minutes, while preserving exosome activity. Furthermore, the system enables direct molecular fingerprinting without the need for complex sample preparation or extraction processes, thereby minimizing contamination risks and sample loss. Using this approach, we successfully identified potential pancreatic cancer biomarkers, including lactate, LPC(18:1), and PC(34:1), from the enriched exosomes, demonstrating the platform's significant potential for both diagnostic and therapeutic applications in cancer research.",

keywords = "Digital Microfluidics, Exosome, Micropillar Arrays, Miniature Mass Spectrometry, Molecular Fingerprinting",

author = "Menglei Zhao and Liyuan Guo and Gong Li and Haobing Liu and Rongxin Fu and Kangfu Chen and Hang Li and Shuailong Zhang",

note = "Publisher Copyright: {\textcopyright} 2026 IEEE.; 39th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2026 ; Conference date: 25-01-2026 Through 29-01-2026",

year = "2026",

doi = "10.1109/MEMS64181.2026.11419330",

language = "English",

series = "Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

pages = "167--170",

booktitle = "2026 IEEE 39th International Conference on Micro Electro Mechanical Systems, MEMS 2026",

address = "United States",

}

Zhao, M, Guo, L, Li, G, Liu, H, Fu, R, Chen, K, Li, H & Zhang, S 2026, An Integrated Digital Microfluidic Platform with Functional Micropillar Arrays and Miniature Mass Spectrometry for Exosome Isolation and Molecular Fingerprinting. 在 2026 IEEE 39th International Conference on Micro Electro Mechanical Systems, MEMS 2026. Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS), Institute of Electrical and Electronics Engineers Inc., 页码 167-170, 39th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2026, Salzburg, 奥地利, 25/01/26. https://doi.org/10.1109/MEMS64181.2026.11419330

An Integrated Digital Microfluidic Platform with Functional Micropillar Arrays and Miniature Mass Spectrometry for Exosome Isolation and Molecular Fingerprinting. / Zhao, Menglei; Guo, Liyuan; Li, Gong 等.
2026 IEEE 39th International Conference on Micro Electro Mechanical Systems, MEMS 2026. Institute of Electrical and Electronics Engineers Inc., 2026. 页码 167-170 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)).

科研成果: 书/报告/会议事项章节 › 会议稿件 › 同行评审

TY - GEN

T1 - An Integrated Digital Microfluidic Platform with Functional Micropillar Arrays and Miniature Mass Spectrometry for Exosome Isolation and Molecular Fingerprinting

AU - Zhao, Menglei

AU - Guo, Liyuan

AU - Li, Gong

AU - Liu, Haobing

AU - Fu, Rongxin

AU - Chen, Kangfu

AU - Li, Hang

AU - Zhang, Shuailong

PY - 2026

Y1 - 2026

N2 - This paper presents an innovative digital microfluidic (DMF) platform that integrates functionalized micropillar arrays with a miniature mass spectrometer (mini-MS), offering a powerful and efficient system for exosome enrichment and analysis. The platform facilitates rapid and automated exosome isolation from ultratrace biological samples (1 μ L), achieving a 96% recovery rate within 20 minutes, while preserving exosome activity. Furthermore, the system enables direct molecular fingerprinting without the need for complex sample preparation or extraction processes, thereby minimizing contamination risks and sample loss. Using this approach, we successfully identified potential pancreatic cancer biomarkers, including lactate, LPC(18:1), and PC(34:1), from the enriched exosomes, demonstrating the platform's significant potential for both diagnostic and therapeutic applications in cancer research.

AB - This paper presents an innovative digital microfluidic (DMF) platform that integrates functionalized micropillar arrays with a miniature mass spectrometer (mini-MS), offering a powerful and efficient system for exosome enrichment and analysis. The platform facilitates rapid and automated exosome isolation from ultratrace biological samples (1 μ L), achieving a 96% recovery rate within 20 minutes, while preserving exosome activity. Furthermore, the system enables direct molecular fingerprinting without the need for complex sample preparation or extraction processes, thereby minimizing contamination risks and sample loss. Using this approach, we successfully identified potential pancreatic cancer biomarkers, including lactate, LPC(18:1), and PC(34:1), from the enriched exosomes, demonstrating the platform's significant potential for both diagnostic and therapeutic applications in cancer research.

KW - Digital Microfluidics

KW - Exosome

KW - Micropillar Arrays

KW - Miniature Mass Spectrometry

KW - Molecular Fingerprinting

UR - https://www.scopus.com/pages/publications/105041723618

U2 - 10.1109/MEMS64181.2026.11419330

DO - 10.1109/MEMS64181.2026.11419330

M3 - Conference contribution

AN - SCOPUS:105041723618

T3 - Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)

SP - 167

EP - 170

BT - 2026 IEEE 39th International Conference on Micro Electro Mechanical Systems, MEMS 2026

PB - Institute of Electrical and Electronics Engineers Inc.

T2 - 39th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2026

Y2 - 25 January 2026 through 29 January 2026

ER -

Zhao M, Guo L, Li G, Liu H, Fu R, Chen K 等. An Integrated Digital Microfluidic Platform with Functional Micropillar Arrays and Miniature Mass Spectrometry for Exosome Isolation and Molecular Fingerprinting. 在 2026 IEEE 39th International Conference on Micro Electro Mechanical Systems, MEMS 2026. Institute of Electrical and Electronics Engineers Inc. 2026. 页码 167-170. (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)). doi: 10.1109/MEMS64181.2026.11419330

An Integrated Digital Microfluidic Platform with Functional Micropillar Arrays and Miniature Mass Spectrometry for Exosome Isolation and Molecular Fingerprinting

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