Advances in the Treatment of Sensorineural Hearing Loss: From Traditional Therapies to Stem Cell and Gene Therapies

Ruirui Chen; Yang Zhang; Zhe Li; Renjie Chai

doi:10.1002/adsr.202500180

Advances in the Treatment of Sensorineural Hearing Loss: From Traditional Therapies to Stem Cell and Gene Therapies

Ruirui Chen
, Yang Zhang^*
, Zhe Li^*
, Renjie Chai^*

^*此作品的通讯作者

Beijing Institute of Technology
Shenzhen Institute of Advanced Technology
Southeast University, Nanjing
Nantong University
University of Electronic Science and Technology of China
Southeast University Shenzhen Research Institute

科研成果: 期刊稿件 › 文献综述 › 同行评审

摘要

Sensorineural hearing loss (SNHL) occurs in 1.5 billion globally, primary driven by damage of cochlear hair cells and spiral ganglion neurons. This review systematically describes several treatment strategies for SNHL. Traditional treatments such as drug therapies consisting of direct drug delivery and carrier-mediated drug delivery, and physical therapies including hearing aids and hearing implants, have limitations. Emerging stem cell therapy shows promise in regenerating damaged inner ear hair cells, while gene therapy targets key deafness genes, offering potential cures for hereditary hearing loss. Future research should focus on optimizing these strategies to overcome current challenges and improve outcomes for patients with SNHL.

源语言	英语
文章编号	e00180
期刊	Advanced Sensor Research
卷	5
期	4
DOI	https://doi.org/10.1002/adsr.202500180
出版状态	已出版 - 4月 2026
已对外发布	是

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title = "Advances in the Treatment of Sensorineural Hearing Loss: From Traditional Therapies to Stem Cell and Gene Therapies",

abstract = "Sensorineural hearing loss (SNHL) occurs in 1.5 billion globally, primary driven by damage of cochlear hair cells and spiral ganglion neurons. This review systematically describes several treatment strategies for SNHL. Traditional treatments such as drug therapies consisting of direct drug delivery and carrier-mediated drug delivery, and physical therapies including hearing aids and hearing implants, have limitations. Emerging stem cell therapy shows promise in regenerating damaged inner ear hair cells, while gene therapy targets key deafness genes, offering potential cures for hereditary hearing loss. Future research should focus on optimizing these strategies to overcome current challenges and improve outcomes for patients with SNHL.",

keywords = "drug treatment, gene therapy, organoids, sensorineural hearing loss, stem cell",

author = "Ruirui Chen and Yang Zhang and Zhe Li and Renjie Chai",

note = "Publisher Copyright: {\textcopyright} 2026 The Author(s). Advanced Sensor Research published by Wiley-VCH GmbH.",

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month = apr,

doi = "10.1002/adsr.202500180",

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T1 - Advances in the Treatment of Sensorineural Hearing Loss

T2 - From Traditional Therapies to Stem Cell and Gene Therapies

AU - Chen, Ruirui

AU - Zhang, Yang

AU - Li, Zhe

AU - Chai, Renjie

PY - 2026/4

Y1 - 2026/4

N2 - Sensorineural hearing loss (SNHL) occurs in 1.5 billion globally, primary driven by damage of cochlear hair cells and spiral ganglion neurons. This review systematically describes several treatment strategies for SNHL. Traditional treatments such as drug therapies consisting of direct drug delivery and carrier-mediated drug delivery, and physical therapies including hearing aids and hearing implants, have limitations. Emerging stem cell therapy shows promise in regenerating damaged inner ear hair cells, while gene therapy targets key deafness genes, offering potential cures for hereditary hearing loss. Future research should focus on optimizing these strategies to overcome current challenges and improve outcomes for patients with SNHL.

AB - Sensorineural hearing loss (SNHL) occurs in 1.5 billion globally, primary driven by damage of cochlear hair cells and spiral ganglion neurons. This review systematically describes several treatment strategies for SNHL. Traditional treatments such as drug therapies consisting of direct drug delivery and carrier-mediated drug delivery, and physical therapies including hearing aids and hearing implants, have limitations. Emerging stem cell therapy shows promise in regenerating damaged inner ear hair cells, while gene therapy targets key deafness genes, offering potential cures for hereditary hearing loss. Future research should focus on optimizing these strategies to overcome current challenges and improve outcomes for patients with SNHL.

KW - drug treatment

KW - gene therapy

KW - organoids

KW - sensorineural hearing loss

KW - stem cell

UR - https://www.scopus.com/pages/publications/105036433361

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DO - 10.1002/adsr.202500180

M3 - Review article

AN - SCOPUS:105036433361

SN - 2751-1219

VL - 5

JO - Advanced Sensor Research

JF - Advanced Sensor Research

IS - 4

M1 - e00180

ER -

Advances in the Treatment of Sensorineural Hearing Loss: From Traditional Therapies to Stem Cell and Gene Therapies

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