TY - GEN
T1 - A PET study of discrimination of cerebral glucose metabolism in Alzheimer's disease and mild cognitive impairment
AU - Sun, Haining
AU - Hu, Bin
AU - Yao, Zhijun
AU - Jackson, Mike
PY - 2013
Y1 - 2013
N2 - Imaging cerebral glucose metabolism with positron emission tomography (PET) has been widely used in studying Alzheimer's disease (AD) and mild cognitive impairment (MCI). In this study, we used fluoro-deoxyglucose (FDG) PET images to investigate reduced glucose metabolism in 90 AD subjects, 90 MCI subjects and 90 healthy elderly normal controls (NC). Compared to NC, the AD showed a significant hypometabolism in left and right middle temporal, left cingulate gyrus, medial frontal gyrus and left parahippocampal gyrus. Compared to NC, the MCI showed a significant hypometabolism in the right inferior temporal gyrus and right fusiform gyrus. Compared to MCIs, the AD also showed a significant hypometabolism in left and right middle temporal, left cingulate gyrus, left angular gyrus and right parahippocampal gyrus. This study demonstrates the different cerebral metabolic patterns of AD, MCI and controls. It also shows that glucose metabolism is a sensitive measure of change in cognition and functional ability in AD and MCI, and that might be valuable in predicting future cognitive decline.
AB - Imaging cerebral glucose metabolism with positron emission tomography (PET) has been widely used in studying Alzheimer's disease (AD) and mild cognitive impairment (MCI). In this study, we used fluoro-deoxyglucose (FDG) PET images to investigate reduced glucose metabolism in 90 AD subjects, 90 MCI subjects and 90 healthy elderly normal controls (NC). Compared to NC, the AD showed a significant hypometabolism in left and right middle temporal, left cingulate gyrus, medial frontal gyrus and left parahippocampal gyrus. Compared to NC, the MCI showed a significant hypometabolism in the right inferior temporal gyrus and right fusiform gyrus. Compared to MCIs, the AD also showed a significant hypometabolism in left and right middle temporal, left cingulate gyrus, left angular gyrus and right parahippocampal gyrus. This study demonstrates the different cerebral metabolic patterns of AD, MCI and controls. It also shows that glucose metabolism is a sensitive measure of change in cognition and functional ability in AD and MCI, and that might be valuable in predicting future cognitive decline.
KW - Alzheimer's disease
KW - metabolism
KW - Mild cognitive impairment
KW - PET
UR - https://www.scopus.com/pages/publications/84896271549
U2 - 10.1109/BMEI.2013.6746897
DO - 10.1109/BMEI.2013.6746897
M3 - Conference contribution
AN - SCOPUS:84896271549
SN - 9781479927616
T3 - Proceedings of the 2013 6th International Conference on Biomedical Engineering and Informatics, BMEI 2013
SP - 6
EP - 11
BT - Proceedings of the 2013 6th International Conference on Biomedical Engineering and Informatics, BMEI 2013
PB - IEEE Computer Society
T2 - 6th International Conference on Biomedical Engineering and Informatics, BMEI 2013
Y2 - 16 December 2013 through 18 December 2013
ER -