A novel stereochemistry retention mechanism in the SN2 reaction

Zhexuan Song; Hong Gao; Jing Xie

doi:10.1038/s41467-026-72120-5

A novel stereochemistry retention mechanism in the S_N2 reaction

Zhexuan Song
, Hong Gao^*
, Jing Xie^*

^*此作品的通讯作者

Beijing Institute of Technology
CAS - Institute of Chemistry
University of Chinese Academy of Sciences

科研成果: 期刊稿件 › 评论/辩论

摘要

A recent study by Lu et al. reports the nucleophilic substitution reaction between Cl^‒ and (CH₃)₃CI can proceed via a flip-over mechanism — a new type of S_N2 pathway that retains configuration, discovered through simulations on a full-dimensional potential energy surface.

源语言	英语
文章编号	3946
期刊	Nature Communications
卷	17
期	1
DOI	https://doi.org/10.1038/s41467-026-72120-5
出版状态	已出版 - 12月 2026
已对外发布	是

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title = "A novel stereochemistry retention mechanism in the SN2 reaction",

abstract = "A recent study by Lu et al. reports the nucleophilic substitution reaction between Cl‒ and (CH3)3CI can proceed via a flip-over mechanism — a new type of SN2 pathway that retains configuration, discovered through simulations on a full-dimensional potential energy surface.",

author = "Zhexuan Song and Hong Gao and Jing Xie",

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year = "2026",

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doi = "10.1038/s41467-026-72120-5",

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AU - Gao, Hong

AU - Xie, Jing

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PY - 2026/12

Y1 - 2026/12

N2 - A recent study by Lu et al. reports the nucleophilic substitution reaction between Cl‒ and (CH3)3CI can proceed via a flip-over mechanism — a new type of SN2 pathway that retains configuration, discovered through simulations on a full-dimensional potential energy surface.

AB - A recent study by Lu et al. reports the nucleophilic substitution reaction between Cl‒ and (CH3)3CI can proceed via a flip-over mechanism — a new type of SN2 pathway that retains configuration, discovered through simulations on a full-dimensional potential energy surface.

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DO - 10.1038/s41467-026-72120-5

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AN - SCOPUS:105038089428

SN - 2041-1723

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JO - Nature Communications

JF - Nature Communications

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A novel stereochemistry retention mechanism in the SN2 reaction

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A novel stereochemistry retention mechanism in the S_N2 reaction