A new method for synthesizing carfentanil

Ke Jian Cui; Peng Wang; Zhi Bin Xu; Yan Qing Mi; Zi Hui Meng; Shu Shan Wang

A new method for synthesizing carfentanil

Ke Jian Cui
, Peng Wang
, Zhi Bin Xu
, Yan Qing Mi
, Zi Hui Meng^*
, Shu Shan Wang

^*此作品的通讯作者

机电学院

Beijing Institute of Technology

科研成果: 期刊稿件 › 文章 › 同行评审

1 引用（Scopus）

摘要

A novel method for synthesizing carfentanil is researched in this work. N-Boc-protected piperidinone was used as the starting material. The carfentanil was achieved via synthetic rout involving five steps: Bargellini reaction, N-acylation, methylation, deprotection and N-alkylation. The overall yield of target compound was 31.6%. The structures of intermediates and final product were determined by infrared spectroscopy, nuclear magnetic resonance spectroscopy and mass spectrograph.

源语言	英语
页（从-至）	1082-1085
页数	4
期刊	Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology
卷	32
期	10
出版状态	已出版 - 10月 2012

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引用此

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title = "A new method for synthesizing carfentanil",

abstract = "A novel method for synthesizing carfentanil is researched in this work. N-Boc-protected piperidinone was used as the starting material. The carfentanil was achieved via synthetic rout involving five steps: Bargellini reaction, N-acylation, methylation, deprotection and N-alkylation. The overall yield of target compound was 31.6\%. The structures of intermediates and final product were determined by infrared spectroscopy, nuclear magnetic resonance spectroscopy and mass spectrograph.",

keywords = "Analgesic medicine, Carfentanil, Synthesis",

author = "Cui, \{Ke Jian\} and Peng Wang and Xu, \{Zhi Bin\} and Mi, \{Yan Qing\} and Meng, \{Zi Hui\} and Wang, \{Shu Shan\}",

year = "2012",

month = oct,

language = "English",

volume = "32",

pages = "1082--1085",

journal = "Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology",

issn = "1001-0645",

publisher = "Beijing Institute of Technology",

number = "10",

}

TY - JOUR

T1 - A new method for synthesizing carfentanil

AU - Cui, Ke Jian

AU - Wang, Peng

AU - Xu, Zhi Bin

AU - Mi, Yan Qing

AU - Meng, Zi Hui

AU - Wang, Shu Shan

PY - 2012/10

Y1 - 2012/10

N2 - A novel method for synthesizing carfentanil is researched in this work. N-Boc-protected piperidinone was used as the starting material. The carfentanil was achieved via synthetic rout involving five steps: Bargellini reaction, N-acylation, methylation, deprotection and N-alkylation. The overall yield of target compound was 31.6%. The structures of intermediates and final product were determined by infrared spectroscopy, nuclear magnetic resonance spectroscopy and mass spectrograph.

AB - A novel method for synthesizing carfentanil is researched in this work. N-Boc-protected piperidinone was used as the starting material. The carfentanil was achieved via synthetic rout involving five steps: Bargellini reaction, N-acylation, methylation, deprotection and N-alkylation. The overall yield of target compound was 31.6%. The structures of intermediates and final product were determined by infrared spectroscopy, nuclear magnetic resonance spectroscopy and mass spectrograph.

KW - Analgesic medicine

KW - Carfentanil

KW - Synthesis

UR - https://www.scopus.com/pages/publications/84871822292

M3 - Article

AN - SCOPUS:84871822292

SN - 1001-0645

VL - 32

SP - 1082

EP - 1085

JO - Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology

JF - Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology

IS - 10

ER -

A new method for synthesizing carfentanil

摘要

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