摘要
A novel method for synthesizing carfentanil is researched in this work. N-Boc-protected piperidinone was used as the starting material. The carfentanil was achieved via synthetic rout involving five steps: Bargellini reaction, N-acylation, methylation, deprotection and N-alkylation. The overall yield of target compound was 31.6%. The structures of intermediates and final product were determined by infrared spectroscopy, nuclear magnetic resonance spectroscopy and mass spectrograph.
| 源语言 | 英语 |
|---|---|
| 页（从-至） | 1082-1085 |
| 页数 | 4 |
| 期刊 | Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology |
| 卷 | 32 |
| 期 | 10 |
| 出版状态 | 已出版 - 10月 2012 |