@inproceedings{812ca4382bd2424b84c4b9a520c65d70,
title = "A Microfluidic Chip for Screening High-Producing Hybridomas at the Single-Cell Level",
abstract = "Screening high-producing antibody-secreting cell from heterogeneity mammalian cell line populations is the vital procedure during the long time culture for antibody manufacture. To acquire high-producing cells, we designed a novel microfluidic chip for screening high-producing hybridomas from heterogeneous population at single cell level. All the procedures of hybridoma screening, including single cell trapping, identification, culturing and releasing, are integrated in a single chip. Compared with traditional methods based on limiting dilution, our chip realized higher monoclonal antibody (mAb) yield and shortened the screening period from 10 to 5 days with twice. It is significance that provides foundation to pharmaceutical company of rapidly screening cell lines.",
author = "Zhang, \{Wei K.\} and Ren Li and Fang, \{Zhi G.\} and Hu, \{Zhi Y.\} and Wei, \{Ze W.\} and Qin Li",
note = "Publisher Copyright: {\textcopyright} 2019 IEEE.; 32nd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2019 ; Conference date: 27-01-2019 Through 31-01-2019",
year = "2019",
month = jan,
doi = "10.1109/MEMSYS.2019.8870728",
language = "English",
series = "Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
pages = "422--425",
booktitle = "2019 IEEE 32nd International Conference on Micro Electro Mechanical Systems, MEMS 2019",
address = "United States",
}