膜融合技术赋能抗癌药物与靶点互作

Targeted therapies have been a revolutionary breakthrough in cancer treatment. A key challenge in this area is the efficient delivery of therapeutic agents to cancerous tissues while ensuring enhanced interaction with specific cellular targets. Although various nanoparticle carriers have been developed to facilitate targeted drug delivery, the lysosomal trap remains a significant obstacle, preventing many drugs from effectively reaching their intracellular targets. Membrane fusion, a fundamental biological process, plays a crucial role in the renewal of cellular membrane lipids and the delivery of vesicular contents. By mimicking this natural fusion mechanism, targeted drug delivery to cancer tissues and effective interaction with intracellular targets can be achieved. Given recent advances in the field and the lack of comprehensive reviews, this article reviews the principles and methods of membrane fusion and its role in enabling efficient interactions between anticancer drugs and their targets. Additionally, it reviews the latest applications, current challenges, and potential developments of membrane fusion technologies in cancer treatment.