空间辐射对肠道菌群及其代谢产物和多系统疾病的影响

Maintaining the homeostasis of gut flora is of great significance to protecting human health. Gut flora plays a key role in regulating body functions, such as digestion, metabolism, immunity, and cognition. These physiological functions often depend on the diversity of gut flora, the stability of the bacterial flora structure, and the balance of the microecology. In the outer space, astronauts face many special environmental factors including the space radiation. Space radiation can cause imbalance of gut flora and changes in metabolites, damaging the intestinal barrier function, and further lead to pathological injury to multiple systems such as the intestine, cardiovascular, brain, and lungs. This paper reviews the characteristic changes in gut flora homeostasis and its metabolites under space flight or simulated space radiation, as well as the interaction between gut flora and intestinal damage and other multi-system diseases under radiation effects. It is expected to provide a reference for the further study of the pathological mechanisms upon space radiation and radiation protection measures.