毛蕊花糖苷的生物合成研究进展

Acteoside is a natural product widely found in many plants, which is composed of caffeic acid, hydroxytyrosol, glucose and rhamnose, including anti-inflammatory, antibacterial, antiviral, anti-tumor, antioxidant, analgesic, neuroprotective, improving sexual function, immunomodulatory, and memory protective activities. However, traditional extraction of acteoside and its derivatives from plants have some problems such as low content, low extraction efficiency and environmental pollution. In recent years, the study of heterologous synthesis of plant natural products has been successfully constructed by the rapid development of synthetic biology, which provides a new idea for the efficient production of acteoside. The recent advances of acteoside cell factory which includes the key metabolic biosynthesis elucidations of phenylethanoid glycoside, mining and optimization of key gene components, synthesis of key precursors were summarized.