α-and β-N-furanoribosyl amide: Synthesis and purification

Mu Hua Huang; Yong Chen Gao; Feng Ling Yang; Yun Jun Luo

α-and β-N-furanoribosyl amide: Synthesis and purification

Mu Hua Huang^*
, Yong Chen Gao
, Feng Ling Yang
, Yun Jun Luo

^*此作品的通讯作者

材料学院

Zhengzhou University

科研成果: 期刊稿件 › 文章 › 同行评审

摘要

In order to disclose the role of N-glycosyl amides-containing proteins in the life process, an efficient separation and purification of α-/β-isomers were urgently required. This paper reported a synthesis and purification of two pairs of α-/β-furanoribosyl amide, 6a/6b and 9a/9b. The results show the important role of basic developing solvents to separate α-and β-isomers by thin layer chromatography (TLC). And a high ΔR_f of 0.24 between α- and β-isomers (9a/9b) are achieved, which lead to their easy peperation by flash column chromatography.

源语言	英语
页（从-至）	1085-1089
页数	5
期刊	Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology
卷	34
期	10
出版状态	已出版 - 1 10月 2014

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title = "α-and β-N-furanoribosyl amide: Synthesis and purification",

abstract = "In order to disclose the role of N-glycosyl amides-containing proteins in the life process, an efficient separation and purification of α-/β-isomers were urgently required. This paper reported a synthesis and purification of two pairs of α-/β-furanoribosyl amide, 6a/6b and 9a/9b. The results show the important role of basic developing solvents to separate α-and β-isomers by thin layer chromatography (TLC). And a high ΔRf of 0.24 between α- and β-isomers (9a/9b) are achieved, which lead to their easy peperation by flash column chromatography.",

keywords = "Epimers, Furanoside, N-glycopeptide, N-glycosyl amide, Seperation",

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T1 - α-and β-N-furanoribosyl amide

T2 - Synthesis and purification

AU - Huang, Mu Hua

AU - Gao, Yong Chen

AU - Yang, Feng Ling

AU - Luo, Yun Jun

PY - 2014/10/1

Y1 - 2014/10/1

N2 - In order to disclose the role of N-glycosyl amides-containing proteins in the life process, an efficient separation and purification of α-/β-isomers were urgently required. This paper reported a synthesis and purification of two pairs of α-/β-furanoribosyl amide, 6a/6b and 9a/9b. The results show the important role of basic developing solvents to separate α-and β-isomers by thin layer chromatography (TLC). And a high ΔRf of 0.24 between α- and β-isomers (9a/9b) are achieved, which lead to their easy peperation by flash column chromatography.

AB - In order to disclose the role of N-glycosyl amides-containing proteins in the life process, an efficient separation and purification of α-/β-isomers were urgently required. This paper reported a synthesis and purification of two pairs of α-/β-furanoribosyl amide, 6a/6b and 9a/9b. The results show the important role of basic developing solvents to separate α-and β-isomers by thin layer chromatography (TLC). And a high ΔRf of 0.24 between α- and β-isomers (9a/9b) are achieved, which lead to their easy peperation by flash column chromatography.

KW - Epimers

KW - Furanoside

KW - N-glycopeptide

KW - N-glycosyl amide

KW - Seperation

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JO - Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology

JF - Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology

IS - 10

ER -

α-and β-N-furanoribosyl amide: Synthesis and purification

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