Zn2+-Triggered Drug Release from Biocompatible Zirconium MOFs Equipped with Supramolecular Gates

Li Li Tan; Haiwei Li; Yue Zhou; Yuanyuan Zhang; Xiao Feng; Bo Wang; Ying Wei Yang

doi:10.1002/smll.201500155

Zn²⁺-Triggered Drug Release from Biocompatible Zirconium MOFs Equipped with Supramolecular Gates

Li Li Tan, Haiwei Li, Yue Zhou, Yuanyuan Zhang, Xiao Feng, Bo Wang, Ying Wei Yang^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

194 Citations (Scopus)

Abstract

A new theranostic nanoplatform, comprising of monodisperse zirconium metal-organic frameworks (MOFs) as drug carriers and carboxylatopillar[5]arene-based supramolecular switches as gating entities, is constructed, and controlled drug release triggered by bio-friendly Zn²⁺ ions (abundant in synaptic vesicles) and auxiliary thermal stimulus is realized. This on-command drug delivery system exhibits large pore sizes for drug encapsulation, excellent biodegradability and biocompatibility, extremely low cytotoxicity and premature drug release, and superior dual-stimuli responsiveness, opening a new avenue in targeted drug delivery and controlled release of therapeutic agents, especially in the treatment of central nervous system diseases.

Original language	English
Pages (from-to)	3807-3813
Number of pages	7
Journal	Small
Volume	11
Issue number	31
DOIs	https://doi.org/10.1002/smll.201500155
Publication status	Published - 1 Aug 2015

Keywords

Zn triggers
drug delivery
metal-organic frameworks
pillarene
supramolecular switches
targeted drug release

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10.1002/smll.201500155

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abstract = "A new theranostic nanoplatform, comprising of monodisperse zirconium metal-organic frameworks (MOFs) as drug carriers and carboxylatopillar[5]arene-based supramolecular switches as gating entities, is constructed, and controlled drug release triggered by bio-friendly Zn2+ ions (abundant in synaptic vesicles) and auxiliary thermal stimulus is realized. This on-command drug delivery system exhibits large pore sizes for drug encapsulation, excellent biodegradability and biocompatibility, extremely low cytotoxicity and premature drug release, and superior dual-stimuli responsiveness, opening a new avenue in targeted drug delivery and controlled release of therapeutic agents, especially in the treatment of central nervous system diseases.",

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author = "Tan, {Li Li} and Haiwei Li and Yue Zhou and Yuanyuan Zhang and Xiao Feng and Bo Wang and Yang, {Ying Wei}",

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T1 - Zn2+-Triggered Drug Release from Biocompatible Zirconium MOFs Equipped with Supramolecular Gates

AU - Tan, Li Li

AU - Li, Haiwei

AU - Zhou, Yue

AU - Zhang, Yuanyuan

AU - Feng, Xiao

AU - Wang, Bo

AU - Yang, Ying Wei

PY - 2015/8/1

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Zn²⁺-Triggered Drug Release from Biocompatible Zirconium MOFs Equipped with Supramolecular Gates

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Keywords

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