TY - JOUR
T1 - Whispering-gallery mode-based optical biosensing
T2 - A review on development and applications in ultrasensitive biological detection and bioimaging
AU - Ming, Ruiqi
AU - Ma, Jiyang
AU - Zhang, Ruoyu
AU - Huang, Lili
N1 - Publisher Copyright:
© 2025
PY - 2025/8/22
Y1 - 2025/8/22
N2 - Biological detection and bioimaging based on specific optical signal changes have succeeded in recent decades. Likewise, a plethora of strategies have emerged to enhance detection sensitivity. Notably, whispering gallery mode (WGM)-based optical biosensing has attracted significant attention due to its high sensitivity and label-free nature. In this review, we present the characterization parameters of WGM resonators in detail and elucidate their relationship with ultrasensitive biological detection and bioimaging. Then, we present emerging design principles and functionalization strategies of WGM resonators. Finally, we thoroughly describe the recent advances of WGM-based optical biosensing technology in different biosensing applications. Thus, we aim to offer fresh insights and stimulate interest among researchers from various domains toward developing and utilizing WGM resonators for biosensing purposes.
AB - Biological detection and bioimaging based on specific optical signal changes have succeeded in recent decades. Likewise, a plethora of strategies have emerged to enhance detection sensitivity. Notably, whispering gallery mode (WGM)-based optical biosensing has attracted significant attention due to its high sensitivity and label-free nature. In this review, we present the characterization parameters of WGM resonators in detail and elucidate their relationship with ultrasensitive biological detection and bioimaging. Then, we present emerging design principles and functionalization strategies of WGM resonators. Finally, we thoroughly describe the recent advances of WGM-based optical biosensing technology in different biosensing applications. Thus, we aim to offer fresh insights and stimulate interest among researchers from various domains toward developing and utilizing WGM resonators for biosensing purposes.
KW - Biological detection
KW - Biological imaging
KW - High sensitivity
KW - Optical biosensing
KW - Whispering gallery mode
UR - http://www.scopus.com/inward/record.url?scp=105006941534&partnerID=8YFLogxK
U2 - 10.1016/j.aca.2025.344249
DO - 10.1016/j.aca.2025.344249
M3 - Review article
AN - SCOPUS:105006941534
SN - 0003-2670
VL - 1364
JO - Analytica Chimica Acta
JF - Analytica Chimica Acta
M1 - 344249
ER -