Water-Soluble Polythiophene for Two-Photon Excitation Fluorescence Imaging and Photodynamic Therapy of Cancer

Minhuan Lan; Shaojing Zhao; Yusheng Xie; Junfang Zhao; Liang Guo; Guangle Niu; Ying Li; Hongyan Sun; Hongyan Zhang; Weimin Liu; Jinyuan Zhang; Pengfei Wang; Wenjun Zhang

doi:10.1021/acsami.6b15537

Water-Soluble Polythiophene for Two-Photon Excitation Fluorescence Imaging and Photodynamic Therapy of Cancer

Minhuan Lan
, Shaojing Zhao
, Yusheng Xie
, Junfang Zhao
, Liang Guo
, Guangle Niu
, Ying Li
, Hongyan Sun
, Hongyan Zhang
, Weimin Liu
, Jinyuan Zhang
, Pengfei Wang^*
, Wenjun Zhang

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

52 Citations (Scopus)

Abstract

Positively charged water-soluble polythiophene (PT0) that could self-assemble into nanoparticles in pure water solution was designed and synthesized. PT0 exhibited high photostabilities and pH stabilities, excellent biocompatibility, strong ¹O₂ generation capability, and large two-photon absorption cross sections. Moreover, we showed that the fluorescence of PT0 was unaffected by the interference of biomolecules and metal ions. As an example application, PT0 was demonstrated to be capable of simultaneous cell imaging and photodynamic therapy under either one-photon or two-photon excitation modes.

Original language	English
Pages (from-to)	14590-14595
Number of pages	6
Journal	ACS Applied Materials and Interfaces
Volume	9
Issue number	17
DOIs	https://doi.org/10.1021/acsami.6b15537
Publication status	Published - 3 May 2017
Externally published	Yes

Keywords

PDT
conjugated polymer
fluorescence imaging
two photon

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/acsami.6b15537

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title = "Water-Soluble Polythiophene for Two-Photon Excitation Fluorescence Imaging and Photodynamic Therapy of Cancer",

abstract = "Positively charged water-soluble polythiophene (PT0) that could self-assemble into nanoparticles in pure water solution was designed and synthesized. PT0 exhibited high photostabilities and pH stabilities, excellent biocompatibility, strong 1O2 generation capability, and large two-photon absorption cross sections. Moreover, we showed that the fluorescence of PT0 was unaffected by the interference of biomolecules and metal ions. As an example application, PT0 was demonstrated to be capable of simultaneous cell imaging and photodynamic therapy under either one-photon or two-photon excitation modes.",

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author = "Minhuan Lan and Shaojing Zhao and Yusheng Xie and Junfang Zhao and Liang Guo and Guangle Niu and Ying Li and Hongyan Sun and Hongyan Zhang and Weimin Liu and Jinyuan Zhang and Pengfei Wang and Wenjun Zhang",

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doi = "10.1021/acsami.6b15537",

language = "English",

volume = "9",

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TY - JOUR

T1 - Water-Soluble Polythiophene for Two-Photon Excitation Fluorescence Imaging and Photodynamic Therapy of Cancer

AU - Lan, Minhuan

AU - Zhao, Shaojing

AU - Xie, Yusheng

AU - Zhao, Junfang

AU - Guo, Liang

AU - Niu, Guangle

AU - Li, Ying

AU - Sun, Hongyan

AU - Zhang, Hongyan

AU - Liu, Weimin

AU - Zhang, Jinyuan

AU - Wang, Pengfei

AU - Zhang, Wenjun

PY - 2017/5/3

Y1 - 2017/5/3

N2 - Positively charged water-soluble polythiophene (PT0) that could self-assemble into nanoparticles in pure water solution was designed and synthesized. PT0 exhibited high photostabilities and pH stabilities, excellent biocompatibility, strong 1O2 generation capability, and large two-photon absorption cross sections. Moreover, we showed that the fluorescence of PT0 was unaffected by the interference of biomolecules and metal ions. As an example application, PT0 was demonstrated to be capable of simultaneous cell imaging and photodynamic therapy under either one-photon or two-photon excitation modes.

AB - Positively charged water-soluble polythiophene (PT0) that could self-assemble into nanoparticles in pure water solution was designed and synthesized. PT0 exhibited high photostabilities and pH stabilities, excellent biocompatibility, strong 1O2 generation capability, and large two-photon absorption cross sections. Moreover, we showed that the fluorescence of PT0 was unaffected by the interference of biomolecules and metal ions. As an example application, PT0 was demonstrated to be capable of simultaneous cell imaging and photodynamic therapy under either one-photon or two-photon excitation modes.

KW - PDT

KW - conjugated polymer

KW - fluorescence imaging

KW - two photon

UR - https://www.scopus.com/pages/publications/85018986296

U2 - 10.1021/acsami.6b15537

DO - 10.1021/acsami.6b15537

M3 - Article

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AN - SCOPUS:85018986296

SN - 1944-8244

VL - 9

SP - 14590

EP - 14595

JO - ACS Applied Materials and Interfaces

JF - ACS Applied Materials and Interfaces

IS - 17

ER -

Water-Soluble Polythiophene for Two-Photon Excitation Fluorescence Imaging and Photodynamic Therapy of Cancer

Abstract

Keywords

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