Visual Multifunctional Aggregation-Induced Emission-Based Bacterial Cellulose for Killing of Multidrug-Resistant Bacteria

Zipeng Shen; Wei Zhu; Yajia Huang; Jiangjiang Zhang; Yifan Wu; Yinzhen Pan; Guang Yang; Dong Wang; Ying Li; Ben Zhong Tang

doi:10.1002/adhm.202300045

Visual Multifunctional Aggregation-Induced Emission-Based Bacterial Cellulose for Killing of Multidrug-Resistant Bacteria

Zipeng Shen
, Wei Zhu
, Yajia Huang
, Jiangjiang Zhang
, Yifan Wu
, Yinzhen Pan
, Guang Yang
, Dong Wang^*
, Ying Li^*
, Ben Zhong Tang^*

^*Corresponding author for this work

Shenzhen University
Zhejiang Sci-Tech University
Shenzhen Institute of Advanced Technology
Southern University of Science and Technology
Huazhong University of Science and Technology
Guangzhou Medical College
The Chinese University of Hong Kong, Shenzhen

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

Multidrug-resistant (MDR) bacteria-related wound infections are a thorny issue. It is urgent to develop new antibacterial wound dressings that can not only prevent wounds from MDR bacteria infection but also promote wound healing. Herein, an aggregation-induced emission (AIE) molecule BITT-composited bacterial cellulose (BC) is presented as wound dressings. BC-BITT composites have good transparency, making it easy to monitor the wound healing process through the composite membrane. The BC-BITT composites retain the advantages of biocompatible BC, and display photodynamic and photothermal synergistic antibacterial effects under irradiation of a 660 nm laser. Furthermore, the BC-BITT composites show excellent wound healing performance in a mouse full-thickness skin wound model infected by MDR bacteria, simultaneously with negligible toxicity. This work paves a way for treating clinically troublesome wound infections.

Original language	English
Article number	2300045
Journal	Advanced healthcare materials
Volume	12
Issue number	21
DOIs	https://doi.org/10.1002/adhm.202300045
Publication status	Published - 21 Aug 2023
Externally published	Yes

Keywords

aggregation-induced emission
bacterial cellulose
photodynamic/photothermal therapy
wound dressings

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10.1002/adhm.202300045

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title = "Visual Multifunctional Aggregation-Induced Emission-Based Bacterial Cellulose for Killing of Multidrug-Resistant Bacteria",

abstract = "Multidrug-resistant (MDR) bacteria-related wound infections are a thorny issue. It is urgent to develop new antibacterial wound dressings that can not only prevent wounds from MDR bacteria infection but also promote wound healing. Herein, an aggregation-induced emission (AIE) molecule BITT-composited bacterial cellulose (BC) is presented as wound dressings. BC-BITT composites have good transparency, making it easy to monitor the wound healing process through the composite membrane. The BC-BITT composites retain the advantages of biocompatible BC, and display photodynamic and photothermal synergistic antibacterial effects under irradiation of a 660 nm laser. Furthermore, the BC-BITT composites show excellent wound healing performance in a mouse full-thickness skin wound model infected by MDR bacteria, simultaneously with negligible toxicity. This work paves a way for treating clinically troublesome wound infections.",

keywords = "aggregation-induced emission, bacterial cellulose, photodynamic/photothermal therapy, wound dressings",

author = "Zipeng Shen and Wei Zhu and Yajia Huang and Jiangjiang Zhang and Yifan Wu and Yinzhen Pan and Guang Yang and Dong Wang and Ying Li and Tang, \{Ben Zhong\}",

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doi = "10.1002/adhm.202300045",

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T1 - Visual Multifunctional Aggregation-Induced Emission-Based Bacterial Cellulose for Killing of Multidrug-Resistant Bacteria

AU - Shen, Zipeng

AU - Zhu, Wei

AU - Huang, Yajia

AU - Zhang, Jiangjiang

AU - Wu, Yifan

AU - Pan, Yinzhen

AU - Yang, Guang

AU - Wang, Dong

AU - Li, Ying

AU - Tang, Ben Zhong

PY - 2023/8/21

Y1 - 2023/8/21

N2 - Multidrug-resistant (MDR) bacteria-related wound infections are a thorny issue. It is urgent to develop new antibacterial wound dressings that can not only prevent wounds from MDR bacteria infection but also promote wound healing. Herein, an aggregation-induced emission (AIE) molecule BITT-composited bacterial cellulose (BC) is presented as wound dressings. BC-BITT composites have good transparency, making it easy to monitor the wound healing process through the composite membrane. The BC-BITT composites retain the advantages of biocompatible BC, and display photodynamic and photothermal synergistic antibacterial effects under irradiation of a 660 nm laser. Furthermore, the BC-BITT composites show excellent wound healing performance in a mouse full-thickness skin wound model infected by MDR bacteria, simultaneously with negligible toxicity. This work paves a way for treating clinically troublesome wound infections.

AB - Multidrug-resistant (MDR) bacteria-related wound infections are a thorny issue. It is urgent to develop new antibacterial wound dressings that can not only prevent wounds from MDR bacteria infection but also promote wound healing. Herein, an aggregation-induced emission (AIE) molecule BITT-composited bacterial cellulose (BC) is presented as wound dressings. BC-BITT composites have good transparency, making it easy to monitor the wound healing process through the composite membrane. The BC-BITT composites retain the advantages of biocompatible BC, and display photodynamic and photothermal synergistic antibacterial effects under irradiation of a 660 nm laser. Furthermore, the BC-BITT composites show excellent wound healing performance in a mouse full-thickness skin wound model infected by MDR bacteria, simultaneously with negligible toxicity. This work paves a way for treating clinically troublesome wound infections.

KW - aggregation-induced emission

KW - bacterial cellulose

KW - photodynamic/photothermal therapy

KW - wound dressings

UR - https://www.scopus.com/pages/publications/85153760401

U2 - 10.1002/adhm.202300045

DO - 10.1002/adhm.202300045

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AN - SCOPUS:85153760401

SN - 2192-2640

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JO - Advanced healthcare materials

JF - Advanced healthcare materials

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ER -

Visual Multifunctional Aggregation-Induced Emission-Based Bacterial Cellulose for Killing of Multidrug-Resistant Bacteria

Abstract

Keywords

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