Virtual screening and activities in vitro of active components from total phenols part of dragon's blood on promoting blood circulation

Fang Liu; Rong Ji Dai; Yu Lin Deng; Xiu Jie Liu; Fang Lü

doi:10.15918/j.tbit1001-0645.2015.02.021

Virtual screening and activities in vitro of active components from total phenols part of dragon's blood on promoting blood circulation

Fang Liu, Rong Ji Dai, Yu Lin Deng, Xiu Jie Liu, Fang Lü^*

^*Corresponding author for this work

Beijing Institute of Technology

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Active components on promoting blood circulation and removing blood stasis were virtually screened by Discovery Studio with thrombin as receptor and the subjects were determined to be detected the effects on thrombin activities and anti-aggregation in vitro. Experimental data shows that the results of pharmacological effects correspond with that of the virtual screening. The subjects including loureirin A, loureirin B, loureirin C, 7-hydroxy-4'-methoxy flavane, and 4', 7-dihydroxy-homoisoflavane can inhibit the activities of thrombin in vitro effectively. It is hypothesized that they play a crucial role in promoting blood circulation and removing blood stasis.

Original language	English
Pages (from-to)	218-220
Number of pages	3
Journal	Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology
Volume	35
Issue number	2
DOIs	https://doi.org/10.15918/j.tbit1001-0645.2015.02.021
Publication status	Published - 1 Feb 2015

Keywords

Activity
Dragon's blood
Promoting blood circulation and removing blood stasis
Virtual screening

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10.15918/j.tbit1001-0645.2015.02.021

Cite this

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title = "Virtual screening and activities in vitro of active components from total phenols part of dragon's blood on promoting blood circulation",

abstract = "Active components on promoting blood circulation and removing blood stasis were virtually screened by Discovery Studio with thrombin as receptor and the subjects were determined to be detected the effects on thrombin activities and anti-aggregation in vitro. Experimental data shows that the results of pharmacological effects correspond with that of the virtual screening. The subjects including loureirin A, loureirin B, loureirin C, 7-hydroxy-4'-methoxy flavane, and 4', 7-dihydroxy-homoisoflavane can inhibit the activities of thrombin in vitro effectively. It is hypothesized that they play a crucial role in promoting blood circulation and removing blood stasis.",

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author = "Fang Liu and Dai, {Rong Ji} and Deng, {Yu Lin} and Liu, {Xiu Jie} and Fang L{\"u}",

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Virtual screening and activities in vitro of active components from total phenols part of dragon's blood on promoting blood circulation. / Liu, Fang; Dai, Rong Ji ; Deng, Yu Lin et al.
In: Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology, Vol. 35, No. 2, 01.02.2015, p. 218-220.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Virtual screening and activities in vitro of active components from total phenols part of dragon's blood on promoting blood circulation

AU - Liu, Fang

AU - Dai, Rong Ji

AU - Deng, Yu Lin

AU - Liu, Xiu Jie

AU - Lü, Fang

PY - 2015/2/1

Y1 - 2015/2/1

N2 - Active components on promoting blood circulation and removing blood stasis were virtually screened by Discovery Studio with thrombin as receptor and the subjects were determined to be detected the effects on thrombin activities and anti-aggregation in vitro. Experimental data shows that the results of pharmacological effects correspond with that of the virtual screening. The subjects including loureirin A, loureirin B, loureirin C, 7-hydroxy-4'-methoxy flavane, and 4', 7-dihydroxy-homoisoflavane can inhibit the activities of thrombin in vitro effectively. It is hypothesized that they play a crucial role in promoting blood circulation and removing blood stasis.

AB - Active components on promoting blood circulation and removing blood stasis were virtually screened by Discovery Studio with thrombin as receptor and the subjects were determined to be detected the effects on thrombin activities and anti-aggregation in vitro. Experimental data shows that the results of pharmacological effects correspond with that of the virtual screening. The subjects including loureirin A, loureirin B, loureirin C, 7-hydroxy-4'-methoxy flavane, and 4', 7-dihydroxy-homoisoflavane can inhibit the activities of thrombin in vitro effectively. It is hypothesized that they play a crucial role in promoting blood circulation and removing blood stasis.

KW - Activity

KW - Dragon's blood

KW - Promoting blood circulation and removing blood stasis

KW - Virtual screening

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SN - 1001-0645

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JO - Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology

JF - Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology

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ER -

Virtual screening and activities in vitro of active components from total phenols part of dragon's blood on promoting blood circulation

Abstract

Keywords

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