Vessel constriction correlated with local singlet oxygen generation during vascular targeted photodynamic therapy

Lisheng Lin, Yirong Li, Jinde Zhang, Zou Tan, Defu Chen, Shusen Xie, Ying Gu, Buhong Li

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

12 Citations (Scopus)

Abstract

In this study, the vessel constriction was measured as a biological indicator of acute vascular response after vascular targeted photodynamic therapy (V-PDT). During V-PDT treatment, the near-infrared (NIR) singlet oxygen (1O2) luminescence at 1270 nm generated in blood vessels in a dorsal skinfold window chamber model in vivo was directly monitored using a custom built high-sensitive NIR imaging system. In order to compare the acute vascular response, various irradiances with the same light dose were utilized for treatments. The obtained results show that the complete arteriole constriction occurred frequently, while some of the larger veins were constricted partially. For the vessels that have significant constriction after V-PDT, our preliminary data suggest that the vasoconstriction in the selected ROIs are roughly correlated with the local cumulative 1O2 luminescence intensities. This study implies that the 1O2 luminescence dosimetry maybe also effective for evaluating V-PDT efficiency.

Original languageEnglish
Title of host publicationOptics in Health Care and Biomedical Optics VI
EditorsQingming Luo, Yuguo Tang, Xingde Li, Ying Gu
PublisherSPIE
ISBN (Electronic)9781628413410
DOIs
Publication statusPublished - 2014
Externally publishedYes
EventOptics in Health Care and Biomedical Optics VI - Beijing, China
Duration: 9 Oct 201411 Oct 2014

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume9268
ISSN (Print)1605-7422

Conference

ConferenceOptics in Health Care and Biomedical Optics VI
Country/TerritoryChina
CityBeijing
Period9/10/1411/10/14

Keywords

  • Blood vessels
  • Singlet oxygen luminescence
  • Vascular targeted photodynamic therapy
  • Vasoconstriction

Fingerprint

Dive into the research topics of 'Vessel constriction correlated with local singlet oxygen generation during vascular targeted photodynamic therapy'. Together they form a unique fingerprint.

Cite this