Abstract
Among type I photosensitizers, stable organic radicals are superior candidate molecules for hypoxia-overcoming photodynamic therapy. However, their wide applications are limited by complicated preparation processes and poor stabilities. Herein, a nitroxide radical was simply synthesized by introducing a commercially available ‘‘TEMPO’’ moiety. The radical exhibits efficient type-I ROS generation and appreciable photo-cytotoxicity under hypoxia, which open up a new avenue for the exploration of a novel and efficient type-I photosensitizer.
Original language | English |
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Pages (from-to) | 1002-1007 |
Number of pages | 6 |
Journal | Materials Horizons |
Volume | 12 |
Issue number | 3 |
DOIs | |
Publication status | Published - 30 Oct 2024 |