Using a stable radical as an ‘‘electron donor’’ to develop a radical photosensitizer for efficient type-I photodynamic therapy

Xiao Cui, Fang Fang, Huan Chen, Chen Cao, Yafang Xiao, Shuang Tian, Jinfeng Zhang*, Shengliang Li*, Chun Sing Lee*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Among type I photosensitizers, stable organic radicals are superior candidate molecules for hypoxia-overcoming photodynamic therapy. However, their wide applications are limited by complicated preparation processes and poor stabilities. Herein, a nitroxide radical was simply synthesized by introducing a commercially available ‘‘TEMPO’’ moiety. The radical exhibits efficient type-I ROS generation and appreciable photo-cytotoxicity under hypoxia, which open up a new avenue for the exploration of a novel and efficient type-I photosensitizer.

Original languageEnglish
Pages (from-to)1002-1007
Number of pages6
JournalMaterials Horizons
Volume12
Issue number3
DOIs
Publication statusPublished - 30 Oct 2024

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