T1-Mediated Nanosensor for Immunoassay Based on an Activatable MnO2 Nanoassembly

Zixin Liu, Yunlei Xianyu, Wenshu Zheng, Jiangjiang Zhang, Yunjing Luo*, Yiping Chen, Mingling Dong, Jing Wu, Xingyu Jiang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

Current magnetic relaxation switching (MRS) sensors for detection of trace targets in complex samples still suffer from limitations in terms of relatively low sensitivity and poor stability. To meet this challenge, we develop a longitudinal relaxation time (T1)-based nanosensor by using Mn2+ released from the reduction of a MnO2 nanoassembly that can induce the change of T1, and thus can greatly improve the sensitivity and overcome the "hook effect" of conventional MRS. Through the specific interaction between antigen and the antibody-functionalized MnO2 nanoassembly, the T1 signal of Mn2+ released from the nanoassembly is quantitatively determined by the antigen, which allows for highly sensitive and straightforward detection of targets. This approach broadens the applicability of magnetic biosensors and has great potential for applications in early diagnosis of disease biomarkers.

Original languageEnglish
Pages (from-to)2765-2771
Number of pages7
JournalAnalytical Chemistry
Volume90
Issue number4
DOIs
Publication statusPublished - 20 Feb 2018
Externally publishedYes

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