Triazole-gold (TAAu) catalyzed three-component coupling (A3 reaction) towards the synthesis of 2, 4-disubstituted quinoline derivatives

Fusong Zhang; Qi Lai; Xiaodong Shi; Zhiguang Song

doi:10.1016/j.cclet.2018.05.036

Triazole-gold (TAAu) catalyzed three-component coupling (A3 reaction) towards the synthesis of 2, 4-disubstituted quinoline derivatives

Fusong Zhang
, Qi Lai
, Xiaodong Shi^*
, Zhiguang Song

^*Corresponding author for this work

Jilin University
University of South Florida

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

A gold-catalyzed three-component coupling reaction (A3 reaction) was developed as an efficient approach for the synthesis of challenging 2, 4-disubstituted quinoline derivatives. Compared to previously reported Cu/Au bi-catalyst system, this protocol enables achieving A3 reaction only in the presence of triazole-gold catalyst. Notably, 4-alkyl substituted or 2-alkyl substituted quinoline derivatives were obtained with good yields, which highlighted the unique advantage of this new strategy.

Original language	English
Pages (from-to)	392-394
Number of pages	3
Journal	Chinese Chemical Letters
Volume	30
Issue number	2
DOIs	https://doi.org/10.1016/j.cclet.2018.05.036
Publication status	Published - Feb 2019
Externally published	Yes

Keywords

A3 reaction
Gold catalysis
Quinoline
Triazole-gold

Access to Document

10.1016/j.cclet.2018.05.036

Cite this

@article{8d8c837328954406bee2cd381b86b927,

title = "Triazole-gold (TAAu) catalyzed three-component coupling (A3 reaction) towards the synthesis of 2, 4-disubstituted quinoline derivatives",

abstract = "A gold-catalyzed three-component coupling reaction (A3 reaction) was developed as an efficient approach for the synthesis of challenging 2, 4-disubstituted quinoline derivatives. Compared to previously reported Cu/Au bi-catalyst system, this protocol enables achieving A3 reaction only in the presence of triazole-gold catalyst. Notably, 4-alkyl substituted or 2-alkyl substituted quinoline derivatives were obtained with good yields, which highlighted the unique advantage of this new strategy.",

keywords = "A3 reaction, Gold catalysis, Quinoline, Triazole-gold",

author = "Fusong Zhang and Qi Lai and Xiaodong Shi and Zhiguang Song",

note = "Publisher Copyright: {\textcopyright} 2019 The Author",

year = "2019",

month = feb,

doi = "10.1016/j.cclet.2018.05.036",

language = "English",

volume = "30",

pages = "392--394",

journal = "Chinese Chemical Letters",

issn = "1001-8417",

publisher = "Elsevier B.V.",

number = "2",

}

TY - JOUR

T1 - Triazole-gold (TAAu) catalyzed three-component coupling (A3 reaction) towards the synthesis of 2, 4-disubstituted quinoline derivatives

AU - Zhang, Fusong

AU - Lai, Qi

AU - Shi, Xiaodong

AU - Song, Zhiguang

PY - 2019/2

Y1 - 2019/2

N2 - A gold-catalyzed three-component coupling reaction (A3 reaction) was developed as an efficient approach for the synthesis of challenging 2, 4-disubstituted quinoline derivatives. Compared to previously reported Cu/Au bi-catalyst system, this protocol enables achieving A3 reaction only in the presence of triazole-gold catalyst. Notably, 4-alkyl substituted or 2-alkyl substituted quinoline derivatives were obtained with good yields, which highlighted the unique advantage of this new strategy.

AB - A gold-catalyzed three-component coupling reaction (A3 reaction) was developed as an efficient approach for the synthesis of challenging 2, 4-disubstituted quinoline derivatives. Compared to previously reported Cu/Au bi-catalyst system, this protocol enables achieving A3 reaction only in the presence of triazole-gold catalyst. Notably, 4-alkyl substituted or 2-alkyl substituted quinoline derivatives were obtained with good yields, which highlighted the unique advantage of this new strategy.

KW - A3 reaction

KW - Gold catalysis

KW - Quinoline

KW - Triazole-gold

UR - https://www.scopus.com/pages/publications/85047723314

U2 - 10.1016/j.cclet.2018.05.036

DO - 10.1016/j.cclet.2018.05.036

M3 - Article

AN - SCOPUS:85047723314

SN - 1001-8417

VL - 30

SP - 392

EP - 394

JO - Chinese Chemical Letters

JF - Chinese Chemical Letters

IS - 2

ER -

Triazole-gold (TAAu) catalyzed three-component coupling (A3 reaction) towards the synthesis of 2, 4-disubstituted quinoline derivatives

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this