Thiophene-based rhodamine as selectivef luorescence probe for Fe(III) and Al(III) in living cells

Kun Peng Wang; Ju Peng Chen; Si Jie Zhang; Yang Lei; Hua Zhong; Shaojin Chen; Xin Hong Zhou; Zhi Qiang Hu

doi:10.1007/s00216-017-0490-8

Thiophene-based rhodamine as selectivef luorescence probe for Fe(III) and Al(III) in living cells

Kun Peng Wang, Ju Peng Chen, Si Jie Zhang, Yang Lei, Hua Zhong, Shaojin Chen, Xin Hong Zhou, Zhi Qiang Hu^*

^*Corresponding author for this work

Qingdao University of Science and Technology

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

The thiophene-modified rhodamine 6G (GYJ) has been synthesized as a novel chemosensor. The sensor has sufficiently high selectivity and sensitivity for the detection of Fe³⁺ and Al³⁺ ions (M³⁺) by fluorescence and ultraviolet spectroscopy with a strong ability for anti-interference performance. The binding ratio of M³⁺-GYJ complex was determined to be 2:1 according to the Job’s plot. The binding constants for Fe³⁺ and Al³⁺ were calculated to be 3.91 × 10⁸ and 5.26 × 10⁸ M⁻², respectively. All these unique features made it particularly favorable for cellular imaging applications. The obvious fluorescence microscopy experiments demonstrated that the probes could contribute to the detection of Fe³⁺ and Al³⁺ in related cells and biological organs with satisfying resolution. [Figure not available: see fulltext.].

Original language	English
Pages (from-to)	5547-5554
Number of pages	8
Journal	Analytical and Bioanalytical Chemistry
Volume	409
Issue number	23
DOIs	https://doi.org/10.1007/s00216-017-0490-8
Publication status	Published - Sept 2017
Externally published	Yes

Keywords

Al
Cells
Fe
Fluorescence probe
Rhodamine 6G
Spirolactam opening

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10.1007/s00216-017-0490-8

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title = "Thiophene-based rhodamine as selectivef luorescence probe for Fe(III) and Al(III) in living cells",

abstract = "The thiophene-modified rhodamine 6G (GYJ) has been synthesized as a novel chemosensor. The sensor has sufficiently high selectivity and sensitivity for the detection of Fe3+ and Al3+ ions (M3+) by fluorescence and ultraviolet spectroscopy with a strong ability for anti-interference performance. The binding ratio of M3+-GYJ complex was determined to be 2:1 according to the Job{\textquoteright}s plot. The binding constants for Fe3+ and Al3+ were calculated to be 3.91 × 108 and 5.26 × 108 M−2, respectively. All these unique features made it particularly favorable for cellular imaging applications. The obvious fluorescence microscopy experiments demonstrated that the probes could contribute to the detection of Fe3+ and Al3+ in related cells and biological organs with satisfying resolution. [Figure not available: see fulltext.].",

keywords = "Al, Cells, Fe, Fluorescence probe, Rhodamine 6G, Spirolactam opening",

author = "Wang, {Kun Peng} and Chen, {Ju Peng} and Zhang, {Si Jie} and Yang Lei and Hua Zhong and Shaojin Chen and Zhou, {Xin Hong} and Hu, {Zhi Qiang}",

note = "Publisher Copyright: {\textcopyright} 2017, Springer-Verlag GmbH Germany.",

year = "2017",

month = sep,

doi = "10.1007/s00216-017-0490-8",

language = "English",

volume = "409",

pages = "5547--5554",

journal = "Analytical and Bioanalytical Chemistry",

issn = "1618-2642",

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TY - JOUR

T1 - Thiophene-based rhodamine as selectivef luorescence probe for Fe(III) and Al(III) in living cells

AU - Wang, Kun Peng

AU - Chen, Ju Peng

AU - Zhang, Si Jie

AU - Lei, Yang

AU - Zhong, Hua

AU - Chen, Shaojin

AU - Zhou, Xin Hong

AU - Hu, Zhi Qiang

PY - 2017/9

Y1 - 2017/9

N2 - The thiophene-modified rhodamine 6G (GYJ) has been synthesized as a novel chemosensor. The sensor has sufficiently high selectivity and sensitivity for the detection of Fe3+ and Al3+ ions (M3+) by fluorescence and ultraviolet spectroscopy with a strong ability for anti-interference performance. The binding ratio of M3+-GYJ complex was determined to be 2:1 according to the Job’s plot. The binding constants for Fe3+ and Al3+ were calculated to be 3.91 × 108 and 5.26 × 108 M−2, respectively. All these unique features made it particularly favorable for cellular imaging applications. The obvious fluorescence microscopy experiments demonstrated that the probes could contribute to the detection of Fe3+ and Al3+ in related cells and biological organs with satisfying resolution. [Figure not available: see fulltext.].

AB - The thiophene-modified rhodamine 6G (GYJ) has been synthesized as a novel chemosensor. The sensor has sufficiently high selectivity and sensitivity for the detection of Fe3+ and Al3+ ions (M3+) by fluorescence and ultraviolet spectroscopy with a strong ability for anti-interference performance. The binding ratio of M3+-GYJ complex was determined to be 2:1 according to the Job’s plot. The binding constants for Fe3+ and Al3+ were calculated to be 3.91 × 108 and 5.26 × 108 M−2, respectively. All these unique features made it particularly favorable for cellular imaging applications. The obvious fluorescence microscopy experiments demonstrated that the probes could contribute to the detection of Fe3+ and Al3+ in related cells and biological organs with satisfying resolution. [Figure not available: see fulltext.].

KW - Al

KW - Cells

KW - Fe

KW - Fluorescence probe

KW - Rhodamine 6G

KW - Spirolactam opening

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U2 - 10.1007/s00216-017-0490-8

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M3 - Article

C2 - 28717898

AN - SCOPUS:85024478345

SN - 1618-2642

VL - 409

SP - 5547

EP - 5554

JO - Analytical and Bioanalytical Chemistry

JF - Analytical and Bioanalytical Chemistry

IS - 23

ER -

Thiophene-based rhodamine as selectivef luorescence probe for Fe(III) and Al(III) in living cells

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Keywords

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