TY - JOUR
T1 - The Regulatory Mechanism of Rab21 in Human Diseases
AU - Li, Xinjian
AU - Ni, Junjun
AU - Qing, Hong
AU - Quan, Zhenzhen
N1 - Publisher Copyright:
© 2023, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2023/10
Y1 - 2023/10
N2 - Rab proteins are important components of small GTPases and play crucial roles in regulating intracellular transportation and cargo delivery. Maintaining the proper functions of Rab proteins is essential for normal cellular activities such as cell signaling, division, and survival. Due to their vital and irreplaceable role in regulating intracellular vesicle transportation, accumulated researches have shown that the abnormalities of Rab proteins and their effectors are closely related to human diseases. Here, this review focused on Rab21, a member of the Rab family, and introduced the structures and functions of Rab21, as well as the regulatory mechanisms of Rab21 in human diseases, including neurodegenerative diseases, cancer, and inflammation. In summary, we described in detail the role of Rab21 in human diseases and provide insights into the potential of Rab21 as a therapeutic target for diseases.
AB - Rab proteins are important components of small GTPases and play crucial roles in regulating intracellular transportation and cargo delivery. Maintaining the proper functions of Rab proteins is essential for normal cellular activities such as cell signaling, division, and survival. Due to their vital and irreplaceable role in regulating intracellular vesicle transportation, accumulated researches have shown that the abnormalities of Rab proteins and their effectors are closely related to human diseases. Here, this review focused on Rab21, a member of the Rab family, and introduced the structures and functions of Rab21, as well as the regulatory mechanisms of Rab21 in human diseases, including neurodegenerative diseases, cancer, and inflammation. In summary, we described in detail the role of Rab21 in human diseases and provide insights into the potential of Rab21 as a therapeutic target for diseases.
KW - Cancer
KW - GTPase family
KW - Inflammation
KW - Intracellular vesicle transportation
KW - Neurodegenerative diseases
KW - Rab21
UR - http://www.scopus.com/inward/record.url?scp=85163401776&partnerID=8YFLogxK
U2 - 10.1007/s12035-023-03454-0
DO - 10.1007/s12035-023-03454-0
M3 - Review article
C2 - 37369821
AN - SCOPUS:85163401776
SN - 0893-7648
VL - 60
SP - 5944
EP - 5953
JO - Molecular Neurobiology
JF - Molecular Neurobiology
IS - 10
ER -
