The regulation of stem cell fate and its application in neural regeneration

Yuexin He; Xingyu Chen; Minghong He; Zhe Li

doi:10.1002/inmd.70137

The regulation of stem cell fate and its application in neural regeneration

Yuexin He
, Xingyu Chen
, Minghong He
, Zhe Li^*

^*Corresponding author for this work

Beijing Institute of Technology

Research output: Contribution to journal › Review article › peer-review

Abstract

Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and tissue engineering, which involves the comprehensive effect of many factors. The commonly used types of SCs were summarized, and the research progress of regulating the fate of SCs through physical factors, biological factors and chemical factors were discussed. It also reviewed the applications and mechanism of SCs in repairing neurodegenerative diseases, optic nerve injury, auditory nerve injury, traumatic peripheral nerve injury, etc. Finally, the future regulatory strategies and development were prospects. The aim is to provide a new idea and method for the treatment of neural regeneration.

Original language	English
Journal	Interdisciplinary Medicine
DOIs	https://doi.org/10.1002/inmd.70137
Publication status	Accepted/In press - 2026
Externally published	Yes

Keywords

cell fate regulation
nerve injury repair
regenerative medicine
stem cell

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10.1002/inmd.70137

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title = "The regulation of stem cell fate and its application in neural regeneration",

abstract = "Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and tissue engineering, which involves the comprehensive effect of many factors. The commonly used types of SCs were summarized, and the research progress of regulating the fate of SCs through physical factors, biological factors and chemical factors were discussed. It also reviewed the applications and mechanism of SCs in repairing neurodegenerative diseases, optic nerve injury, auditory nerve injury, traumatic peripheral nerve injury, etc. Finally, the future regulatory strategies and development were prospects. The aim is to provide a new idea and method for the treatment of neural regeneration.",

keywords = "cell fate regulation, nerve injury repair, regenerative medicine, stem cell",

author = "Yuexin He and Xingyu Chen and Minghong He and Zhe Li",

note = "Publisher Copyright: {\textcopyright} 2026 The Author(s). Interdisciplinary Medicine published by Wiley-VCH GmbH on behalf of Nanfang Hospital, Southern Medical University.",

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T1 - The regulation of stem cell fate and its application in neural regeneration

AU - He, Yuexin

AU - Chen, Xingyu

AU - He, Minghong

AU - Li, Zhe

PY - 2026

Y1 - 2026

N2 - Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and tissue engineering, which involves the comprehensive effect of many factors. The commonly used types of SCs were summarized, and the research progress of regulating the fate of SCs through physical factors, biological factors and chemical factors were discussed. It also reviewed the applications and mechanism of SCs in repairing neurodegenerative diseases, optic nerve injury, auditory nerve injury, traumatic peripheral nerve injury, etc. Finally, the future regulatory strategies and development were prospects. The aim is to provide a new idea and method for the treatment of neural regeneration.

AB - Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and tissue engineering, which involves the comprehensive effect of many factors. The commonly used types of SCs were summarized, and the research progress of regulating the fate of SCs through physical factors, biological factors and chemical factors were discussed. It also reviewed the applications and mechanism of SCs in repairing neurodegenerative diseases, optic nerve injury, auditory nerve injury, traumatic peripheral nerve injury, etc. Finally, the future regulatory strategies and development were prospects. The aim is to provide a new idea and method for the treatment of neural regeneration.

KW - cell fate regulation

KW - nerve injury repair

KW - regenerative medicine

KW - stem cell

UR - https://www.scopus.com/pages/publications/105042449550

U2 - 10.1002/inmd.70137

DO - 10.1002/inmd.70137

M3 - Review article

AN - SCOPUS:105042449550

SN - 2832-6237

JO - Interdisciplinary Medicine

JF - Interdisciplinary Medicine

ER -

The regulation of stem cell fate and its application in neural regeneration

Abstract

Keywords

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