The Ethanol Supernatant Extracts of Liushenwan Could Alleviate Nanodiethylnitrosamine-Induced Liver Cancer in Mice

Xi Zhen Chen; Wei Kevin Zhang; He Bin Tang; Xiao Jun Li; Gui Hua Tian; Hong Cai Shang; Yu Sang Li

doi:10.1155/2018/6934809

The Ethanol Supernatant Extracts of Liushenwan Could Alleviate Nanodiethylnitrosamine-Induced Liver Cancer in Mice

Xi Zhen Chen
, Wei Kevin Zhang
, He Bin Tang
, Xiao Jun Li
, Gui Hua Tian^*
, Hong Cai Shang
, Yu Sang Li

^*Corresponding author for this work

South-Central University for Nationalities
Beijing University of Chinese Medicine

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Liver cancer is one of the leading causes of cancerous deaths worldwide. At present, the treatment of hepatocellular carcinoma (HCC) remains to be a problem globally. Liushenwan (LSW), an ancient Chinese medicine previously used to treat localized infections, was recently reported to possess anticancer activity. Here in this study, we aim to examine the effect of LSW-ET (LSW-ET is the supernatant fraction of LSW from ultrasound assisted ethanol extraction) in prevention and treatment on nanodiethylnitrosamine- (nanoDEN-) induced HCC in mice. In nanoDEN-induced HCC mice treated with LSW-ET by oral (po) or intragastric gavage (ig), we observed an alleviation of serum ALT and AST levels, amelioration in histopathological stainings, and an inhibition in liver tumor growth. In addition, compared with the nanoDEN group, downregulation of multiple pivotal factors (COX-2, β-catenin, PCNA, and HMGB-1) was observed in LSW-ET-po and LSW-ET-ig groups. Taken together, the delivery of LSW-ET by oral could be a potential prevention and treatment of liver cancer.

Original language	English
Article number	6934809
Journal	Canadian Journal of Gastroenterology and Hepatology
Volume	2018
DOIs	https://doi.org/10.1155/2018/6934809
Publication status	Published - 2018
Externally published	Yes

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SDG 3 Good Health and Well-being

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10.1155/2018/6934809

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@article{7014f0bb66a34cfc815a0bd540f82843,

title = "The Ethanol Supernatant Extracts of Liushenwan Could Alleviate Nanodiethylnitrosamine-Induced Liver Cancer in Mice",

abstract = "Liver cancer is one of the leading causes of cancerous deaths worldwide. At present, the treatment of hepatocellular carcinoma (HCC) remains to be a problem globally. Liushenwan (LSW), an ancient Chinese medicine previously used to treat localized infections, was recently reported to possess anticancer activity. Here in this study, we aim to examine the effect of LSW-ET (LSW-ET is the supernatant fraction of LSW from ultrasound assisted ethanol extraction) in prevention and treatment on nanodiethylnitrosamine- (nanoDEN-) induced HCC in mice. In nanoDEN-induced HCC mice treated with LSW-ET by oral (po) or intragastric gavage (ig), we observed an alleviation of serum ALT and AST levels, amelioration in histopathological stainings, and an inhibition in liver tumor growth. In addition, compared with the nanoDEN group, downregulation of multiple pivotal factors (COX-2, β-catenin, PCNA, and HMGB-1) was observed in LSW-ET-po and LSW-ET-ig groups. Taken together, the delivery of LSW-ET by oral could be a potential prevention and treatment of liver cancer.",

author = "Chen, \{Xi Zhen\} and Zhang, \{Wei Kevin\} and Tang, \{He Bin\} and Li, \{Xiao Jun\} and Tian, \{Gui Hua\} and Shang, \{Hong Cai\} and Li, \{Yu Sang\}",

note = "Publisher Copyright: {\textcopyright} 2018 Xi-Zhen Chen et al.",

year = "2018",

doi = "10.1155/2018/6934809",

language = "English",

volume = "2018",

journal = "Canadian Journal of Gastroenterology and Hepatology",

issn = "2291-2789",

publisher = "John Wiley and Sons Ltd",

}

TY - JOUR

T1 - The Ethanol Supernatant Extracts of Liushenwan Could Alleviate Nanodiethylnitrosamine-Induced Liver Cancer in Mice

AU - Chen, Xi Zhen

AU - Zhang, Wei Kevin

AU - Tang, He Bin

AU - Li, Xiao Jun

AU - Tian, Gui Hua

AU - Shang, Hong Cai

AU - Li, Yu Sang

PY - 2018

Y1 - 2018

N2 - Liver cancer is one of the leading causes of cancerous deaths worldwide. At present, the treatment of hepatocellular carcinoma (HCC) remains to be a problem globally. Liushenwan (LSW), an ancient Chinese medicine previously used to treat localized infections, was recently reported to possess anticancer activity. Here in this study, we aim to examine the effect of LSW-ET (LSW-ET is the supernatant fraction of LSW from ultrasound assisted ethanol extraction) in prevention and treatment on nanodiethylnitrosamine- (nanoDEN-) induced HCC in mice. In nanoDEN-induced HCC mice treated with LSW-ET by oral (po) or intragastric gavage (ig), we observed an alleviation of serum ALT and AST levels, amelioration in histopathological stainings, and an inhibition in liver tumor growth. In addition, compared with the nanoDEN group, downregulation of multiple pivotal factors (COX-2, β-catenin, PCNA, and HMGB-1) was observed in LSW-ET-po and LSW-ET-ig groups. Taken together, the delivery of LSW-ET by oral could be a potential prevention and treatment of liver cancer.

AB - Liver cancer is one of the leading causes of cancerous deaths worldwide. At present, the treatment of hepatocellular carcinoma (HCC) remains to be a problem globally. Liushenwan (LSW), an ancient Chinese medicine previously used to treat localized infections, was recently reported to possess anticancer activity. Here in this study, we aim to examine the effect of LSW-ET (LSW-ET is the supernatant fraction of LSW from ultrasound assisted ethanol extraction) in prevention and treatment on nanodiethylnitrosamine- (nanoDEN-) induced HCC in mice. In nanoDEN-induced HCC mice treated with LSW-ET by oral (po) or intragastric gavage (ig), we observed an alleviation of serum ALT and AST levels, amelioration in histopathological stainings, and an inhibition in liver tumor growth. In addition, compared with the nanoDEN group, downregulation of multiple pivotal factors (COX-2, β-catenin, PCNA, and HMGB-1) was observed in LSW-ET-po and LSW-ET-ig groups. Taken together, the delivery of LSW-ET by oral could be a potential prevention and treatment of liver cancer.

UR - https://www.scopus.com/pages/publications/85055596613

U2 - 10.1155/2018/6934809

DO - 10.1155/2018/6934809

M3 - Article

C2 - 30356380

AN - SCOPUS:85055596613

SN - 2291-2789

VL - 2018

JO - Canadian Journal of Gastroenterology and Hepatology

JF - Canadian Journal of Gastroenterology and Hepatology

M1 - 6934809

ER -

The Ethanol Supernatant Extracts of Liushenwan Could Alleviate Nanodiethylnitrosamine-Induced Liver Cancer in Mice

Abstract

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