The direct electrophilic cyanation of β-keto esters and amides with cyano benziodoxole

Yao Feng Wang; Jiashen Qiu; Dejie Kong; Yongtao Gao; Feipeng Lu; Pran Gopal Karmaker; Fu Xue Chen

doi:10.1039/c4ob02032d

The direct electrophilic cyanation of β-keto esters and amides with cyano benziodoxole

Yao Feng Wang, Jiashen Qiu, Dejie Kong, Yongtao Gao, Feipeng Lu, Pran Gopal Karmaker, Fu Xue Chen^*

^*Corresponding author for this work

School of Chemistry and Chemical Engineering

Beijing Institute of Technology

Research output: Contribution to journal › Article › peer-review

59 Citations (Scopus)

Abstract

The direct electrophilic α-cyanation of β-keto esters and amides has been developed using a hypervalent iodine benziodoxole-derived cyano reagent. The procedure is accomplished within 10 min and without the use of any catalyst in DMF, at room temperature. Thus, the highly functionalized quaternary carbon-centered nitriles were produced in high to excellent yields.

Original language	English
Pages (from-to)	365-368
Number of pages	4
Journal	Organic and Biomolecular Chemistry
Volume	13
Issue number	2
DOIs	https://doi.org/10.1039/c4ob02032d
Publication status	Published - 14 Jan 2015

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abstract = "The direct electrophilic α-cyanation of β-keto esters and amides has been developed using a hypervalent iodine benziodoxole-derived cyano reagent. The procedure is accomplished within 10 min and without the use of any catalyst in DMF, at room temperature. Thus, the highly functionalized quaternary carbon-centered nitriles were produced in high to excellent yields.",

author = "Wang, {Yao Feng} and Jiashen Qiu and Dejie Kong and Yongtao Gao and Feipeng Lu and Karmaker, {Pran Gopal} and Chen, {Fu Xue}",

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AU - Wang, Yao Feng

AU - Qiu, Jiashen

AU - Kong, Dejie

AU - Gao, Yongtao

AU - Lu, Feipeng

AU - Karmaker, Pran Gopal

AU - Chen, Fu Xue

PY - 2015/1/14

Y1 - 2015/1/14

N2 - The direct electrophilic α-cyanation of β-keto esters and amides has been developed using a hypervalent iodine benziodoxole-derived cyano reagent. The procedure is accomplished within 10 min and without the use of any catalyst in DMF, at room temperature. Thus, the highly functionalized quaternary carbon-centered nitriles were produced in high to excellent yields.

AB - The direct electrophilic α-cyanation of β-keto esters and amides has been developed using a hypervalent iodine benziodoxole-derived cyano reagent. The procedure is accomplished within 10 min and without the use of any catalyst in DMF, at room temperature. Thus, the highly functionalized quaternary carbon-centered nitriles were produced in high to excellent yields.

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DO - 10.1039/c4ob02032d

M3 - Article

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AN - SCOPUS:84918526272

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EP - 368

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The direct electrophilic cyanation of β-keto esters and amides with cyano benziodoxole

Abstract

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