Abstract
(Chemical Equation Presented) Building a better scaffold: Low loadings (0.2-1 mol%) of new double axially chiral phosphoric acid catalysts 1 based on bisbinol scaffold were used for asymmetric transfer hydrogenation. 2-Aryl- and 2-alkyl-substituted quinolines gave tetrahydroquinolines in excellent yields and with up to 98% ee and 2,3-disubstituted tetrahydroquinolines were prepared in high diastereo- and enantioselectivities (up to > 20:1 and 92% ee).
Original language | English |
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Pages (from-to) | 759-762 |
Number of pages | 4 |
Journal | Angewandte Chemie - International Edition |
Volume | 47 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2008 |
Externally published | Yes |
Keywords
- Asymmetric synthesis
- Brønsted acid
- Hydrogenation
- Organocatalysis
- Tetrahydroquinolines