The Application of Chiral Porous Organic Materials in Chiral Separation

Chirality is a phenomenon that widely exists in nature. Chiral separation is significant in biochemical fields such as pharmacology，catalysis，and pesticide chemistry. Chiral porous organic materials are emerging materials with unique structures and functions that demonstrate huge potential applications in the field of chiral separation. These materials mainly include chiral metal-organic frameworks（CMOFs）， chiral covalent organic frameworks（CCOFs）， chiral porous organic cages （CPOCs），and so on. Due to their characteristics such as high porosity，large specific surface area， and flexibly adjustable pore structures， they have shown extensive application values in fields like gas adsorption，molecular separation，and chiral catalysis. Firstly，this article introduces the clas⁃ sifications of some typical chiral porous organic materials， as well as synthesis methods such as di⁃ rect synthesis，post-modification synthesis，chiral induction，and self-assembly. It mainly summa⁃ rizes the latest applications of chiral porous organic materials as chiral separation media in the chro⁃ matographic field in recent years， including gas chromatography（GC）， high-performance liquid chromatography（HPLC），capillary electrochromatography（CEC），and membrane separation. Final⁃ ly，it briefly outlines the difficulties and challenges existing in chiral separation when chiral porous organic materials are used as media and their future development trends.