Targeting Programmed Cell Death in Acquired Sensorineural Hearing Loss: Ferroptosis, Necroptosis, and Pyroptosis

Shasha Zhang; Hairong Xiao; Yanqin Lin; Xujun Tang; Wei Tong; Buwei Shao; He Li; Lei Xu; Xiaoqiong Ding; Renjie Chai

doi:10.1007/s12264-025-01370-y

Targeting Programmed Cell Death in Acquired Sensorineural Hearing Loss: Ferroptosis, Necroptosis, and Pyroptosis

Shasha Zhang^*, Hairong Xiao, Yanqin Lin, Xujun Tang, Wei Tong, Buwei Shao, He Li^*, Lei Xu^*, Xiaoqiong Ding^*, Renjie Chai^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

Sensorineural hearing loss (SNHL), the most commonly-occurring form of hearing loss, is caused mainly by injury to or the loss of hair cells and spiral ganglion neurons in the cochlea. Numerous environmental and physiological factors have been shown to cause acquired SNHL, such as ototoxic drugs, noise exposure, aging, infections, and diseases. Several programmed cell death (PCD) pathways have been reported to be involved in SNHL, especially some novel PCD pathways that have only recently been reported, such as ferroptosis, necroptosis, and pyroptosis. Here we summarize these PCD pathways and their roles and mechanisms in SNHL, aiming to provide new insights and potential therapeutic strategies for SNHL by targeting these PCD pathways.

Original language	English
Article number	829564
Journal	Neuroscience Bulletin
DOIs	https://doi.org/10.1007/s12264-025-01370-y
Publication status	Accepted/In press - 2025
Externally published	Yes

Keywords

Ferroptosis
Necroptosis
Programmed cell death
Pyroptosis
Sensorineural hearing loss

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10.1007/s12264-025-01370-y

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title = "Targeting Programmed Cell Death in Acquired Sensorineural Hearing Loss: Ferroptosis, Necroptosis, and Pyroptosis",

abstract = "Sensorineural hearing loss (SNHL), the most commonly-occurring form of hearing loss, is caused mainly by injury to or the loss of hair cells and spiral ganglion neurons in the cochlea. Numerous environmental and physiological factors have been shown to cause acquired SNHL, such as ototoxic drugs, noise exposure, aging, infections, and diseases. Several programmed cell death (PCD) pathways have been reported to be involved in SNHL, especially some novel PCD pathways that have only recently been reported, such as ferroptosis, necroptosis, and pyroptosis. Here we summarize these PCD pathways and their roles and mechanisms in SNHL, aiming to provide new insights and potential therapeutic strategies for SNHL by targeting these PCD pathways.",

keywords = "Ferroptosis, Necroptosis, Programmed cell death, Pyroptosis, Sensorineural hearing loss",

author = "Shasha Zhang and Hairong Xiao and Yanqin Lin and Xujun Tang and Wei Tong and Buwei Shao and He Li and Lei Xu and Xiaoqiong Ding and Renjie Chai",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2025.",

year = "2025",

doi = "10.1007/s12264-025-01370-y",

language = "English",

journal = "Neuroscience Bulletin",

issn = "1673-7067",

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TY - JOUR

T1 - Targeting Programmed Cell Death in Acquired Sensorineural Hearing Loss

T2 - Ferroptosis, Necroptosis, and Pyroptosis

AU - Zhang, Shasha

AU - Xiao, Hairong

AU - Lin, Yanqin

AU - Tang, Xujun

AU - Tong, Wei

AU - Shao, Buwei

AU - Li, He

AU - Xu, Lei

AU - Ding, Xiaoqiong

AU - Chai, Renjie

N1 - Publisher Copyright: © The Author(s) 2025.

PY - 2025

Y1 - 2025

N2 - Sensorineural hearing loss (SNHL), the most commonly-occurring form of hearing loss, is caused mainly by injury to or the loss of hair cells and spiral ganglion neurons in the cochlea. Numerous environmental and physiological factors have been shown to cause acquired SNHL, such as ototoxic drugs, noise exposure, aging, infections, and diseases. Several programmed cell death (PCD) pathways have been reported to be involved in SNHL, especially some novel PCD pathways that have only recently been reported, such as ferroptosis, necroptosis, and pyroptosis. Here we summarize these PCD pathways and their roles and mechanisms in SNHL, aiming to provide new insights and potential therapeutic strategies for SNHL by targeting these PCD pathways.

AB - Sensorineural hearing loss (SNHL), the most commonly-occurring form of hearing loss, is caused mainly by injury to or the loss of hair cells and spiral ganglion neurons in the cochlea. Numerous environmental and physiological factors have been shown to cause acquired SNHL, such as ototoxic drugs, noise exposure, aging, infections, and diseases. Several programmed cell death (PCD) pathways have been reported to be involved in SNHL, especially some novel PCD pathways that have only recently been reported, such as ferroptosis, necroptosis, and pyroptosis. Here we summarize these PCD pathways and their roles and mechanisms in SNHL, aiming to provide new insights and potential therapeutic strategies for SNHL by targeting these PCD pathways.

KW - Ferroptosis

KW - Necroptosis

KW - Programmed cell death

KW - Pyroptosis

KW - Sensorineural hearing loss

UR - http://www.scopus.com/inward/record.url?scp=105003390308&partnerID=8YFLogxK

U2 - 10.1007/s12264-025-01370-y

DO - 10.1007/s12264-025-01370-y

M3 - Review article

AN - SCOPUS:105003390308

SN - 1673-7067

JO - Neuroscience Bulletin

JF - Neuroscience Bulletin

M1 - 829564

ER -

Targeting Programmed Cell Death in Acquired Sensorineural Hearing Loss: Ferroptosis, Necroptosis, and Pyroptosis

Abstract

Keywords

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