Targeting peptide-mediated nanoparticle transport and antitumor efficacy research based on spatial proteomics

Limin Zhang; Zhiwei Yin; Minxuan Wang; Beilei Sun; Bo Wang; Kai Han; Jinge Zhao; Mingshan Wei; Jingrui Deng; Weizhi Wang

doi:10.1039/d6cc02928k

Targeting peptide-mediated nanoparticle transport and antitumor efficacy research based on spatial proteomics

Limin Zhang
, Zhiwei Yin
, Minxuan Wang
, Beilei Sun
, Bo Wang
, Kai Han
, Jinge Zhao
, Mingshan Wei
, Jingrui Deng
, Weizhi Wang^*

^*Corresponding author for this work

The University of Hong Kong
Beijing Institute of Technology

Research output: Contribution to journal › Article › peer-review

Abstract

Nanoparticle-based drugs face challenges of weak spatiotemporal control and difficulty in elucidating their mechanisms of action. We designed a stimulus-responsive delivery system based on targeted peptides and quantum dots (QDs) to achieve synergistic therapy combining sonodynamic therapy (SDT) and immune checkpoint blockade (ICB). Using spatially resolved proteomics technology, we analyzed the mechanism underlying this synergy.

Original language	English
Pages (from-to)	15335-15338
Number of pages	4
Journal	Chemical Communications
Volume	62
Issue number	61
DOIs	https://doi.org/10.1039/d6cc02928k
Publication status	Published - 6 Aug 2026
Externally published	Yes

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10.1039/d6cc02928k

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title = "Targeting peptide-mediated nanoparticle transport and antitumor efficacy research based on spatial proteomics",

abstract = "Nanoparticle-based drugs face challenges of weak spatiotemporal control and difficulty in elucidating their mechanisms of action. We designed a stimulus-responsive delivery system based on targeted peptides and quantum dots (QDs) to achieve synergistic therapy combining sonodynamic therapy (SDT) and immune checkpoint blockade (ICB). Using spatially resolved proteomics technology, we analyzed the mechanism underlying this synergy.",

author = "Limin Zhang and Zhiwei Yin and Minxuan Wang and Beilei Sun and Bo Wang and Kai Han and Jinge Zhao and Mingshan Wei and Jingrui Deng and Weizhi Wang",

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T1 - Targeting peptide-mediated nanoparticle transport and antitumor efficacy research based on spatial proteomics

AU - Zhang, Limin

AU - Yin, Zhiwei

AU - Wang, Minxuan

AU - Sun, Beilei

AU - Wang, Bo

AU - Han, Kai

AU - Zhao, Jinge

AU - Wei, Mingshan

AU - Deng, Jingrui

AU - Wang, Weizhi

PY - 2026/8/6

Y1 - 2026/8/6

N2 - Nanoparticle-based drugs face challenges of weak spatiotemporal control and difficulty in elucidating their mechanisms of action. We designed a stimulus-responsive delivery system based on targeted peptides and quantum dots (QDs) to achieve synergistic therapy combining sonodynamic therapy (SDT) and immune checkpoint blockade (ICB). Using spatially resolved proteomics technology, we analyzed the mechanism underlying this synergy.

AB - Nanoparticle-based drugs face challenges of weak spatiotemporal control and difficulty in elucidating their mechanisms of action. We designed a stimulus-responsive delivery system based on targeted peptides and quantum dots (QDs) to achieve synergistic therapy combining sonodynamic therapy (SDT) and immune checkpoint blockade (ICB). Using spatially resolved proteomics technology, we analyzed the mechanism underlying this synergy.

UR - https://www.scopus.com/pages/publications/105045346588

U2 - 10.1039/d6cc02928k

DO - 10.1039/d6cc02928k

M3 - Article

AN - SCOPUS:105045346588

SN - 1359-7345

VL - 62

SP - 15335

EP - 15338

JO - Chemical Communications

JF - Chemical Communications

IS - 61

ER -

Targeting peptide-mediated nanoparticle transport and antitumor efficacy research based on spatial proteomics

Abstract

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