Tandem electrophilic thiocyanation/cyclization of α-alkynyl oximes for synthesis of 4-thiocyanatoisoxazoles

Xiaowei Liu; Chukai Shao; Hongquan Yin; Kaixiang Liu; Fu Xue Chen

doi:10.1039/d5nj03863d

Tandem electrophilic thiocyanation/cyclization of α-alkynyl oximes for synthesis of 4-thiocyanatoisoxazoles

Xiaowei Liu
, Chukai Shao
, Hongquan Yin
, Kaixiang Liu
, Fu Xue Chen^*

^*Corresponding author for this work

School of Chemistry and Chemical Engineering

Research output: Contribution to journal › Article › peer-review

Abstract

A tandem electrophilic thiocyanation/cyclization of 1,3-diphenyl-2-propyn-1-one O-methyloxime has been achieved under mild conditions. This method provides efficient access to a series of thiocyanato-containing isoxazole derivatives in moderate to excellent yields, demonstrating broad substrate scope and good functional group tolerance.

Original language	English
Journal	New Journal of Chemistry
DOIs	https://doi.org/10.1039/d5nj03863d
Publication status	Accepted/In press - 2026

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10.1039/d5nj03863d

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title = "Tandem electrophilic thiocyanation/cyclization of α-alkynyl oximes for synthesis of 4-thiocyanatoisoxazoles",

abstract = "A tandem electrophilic thiocyanation/cyclization of 1,3-diphenyl-2-propyn-1-one O-methyloxime has been achieved under mild conditions. This method provides efficient access to a series of thiocyanato-containing isoxazole derivatives in moderate to excellent yields, demonstrating broad substrate scope and good functional group tolerance.",

author = "Xiaowei Liu and Chukai Shao and Hongquan Yin and Kaixiang Liu and Chen, \{Fu Xue\}",

note = "Publisher Copyright: This journal is {\textcopyright} The Royal Society of Chemistry and the Centre National de la Recherche Scientifique, 2026",

year = "2026",

doi = "10.1039/d5nj03863d",

language = "English",

journal = "New Journal of Chemistry",

issn = "1144-0546",

publisher = "Royal Society of Chemistry",

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T1 - Tandem electrophilic thiocyanation/cyclization of α-alkynyl oximes for synthesis of 4-thiocyanatoisoxazoles

AU - Liu, Xiaowei

AU - Shao, Chukai

AU - Yin, Hongquan

AU - Liu, Kaixiang

AU - Chen, Fu Xue

N1 - Publisher Copyright: This journal is © The Royal Society of Chemistry and the Centre National de la Recherche Scientifique, 2026

PY - 2026

Y1 - 2026

N2 - A tandem electrophilic thiocyanation/cyclization of 1,3-diphenyl-2-propyn-1-one O-methyloxime has been achieved under mild conditions. This method provides efficient access to a series of thiocyanato-containing isoxazole derivatives in moderate to excellent yields, demonstrating broad substrate scope and good functional group tolerance.

AB - A tandem electrophilic thiocyanation/cyclization of 1,3-diphenyl-2-propyn-1-one O-methyloxime has been achieved under mild conditions. This method provides efficient access to a series of thiocyanato-containing isoxazole derivatives in moderate to excellent yields, demonstrating broad substrate scope and good functional group tolerance.

UR - https://www.scopus.com/pages/publications/105030371574

U2 - 10.1039/d5nj03863d

DO - 10.1039/d5nj03863d

M3 - Article

AN - SCOPUS:105030371574

SN - 1144-0546

JO - New Journal of Chemistry

JF - New Journal of Chemistry

ER -

Tandem electrophilic thiocyanation/cyclization of α-alkynyl oximes for synthesis of 4-thiocyanatoisoxazoles

Abstract

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