Synthesis of [13C2,                             15N]-1,3-2H-1-benzyl-(Z)-3-(benzylidene)indolin-2-one

Jixia Yang; Gongzheng Zhang; Zhaoyang Wang; Zhanxiong Xiao; Hongliang Wen

doi:10.1002/jlcr.3796

Synthesis of [¹³C_2, ¹⁵N]-1,3-2H-1-benzyl-(Z)-3-(benzylidene)indolin-2-one

Jixia Yang
, Gongzheng Zhang
, Zhaoyang Wang
, Zhanxiong Xiao
, Hongliang Wen^*

^*Corresponding author for this work

School of Chemistry and Chemical Engineering

Beijing Institute of Technology

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Parkinson disease (PD) is a neurodegenerative disorder characterized by the accumulation of α-synuclein into Lewy bodies. 3-Benzylidine-indolin-2-one represents a class of compounds, which are known to inhibit the accumulation of α-synuclein. In this paper, we report the synthesis of [¹³C] and [¹⁵N] labelled 1-benzyl-(Z)-3-(benzylidene)indolin-2-one from commercially available [¹³C₂]-chloroacetic acid and [¹⁵N]-aniline in five steps. The product will be used to study its metabolites in human liver microsomes by liquid chromatography-tandem mass spectrometry.

Original language	English
Pages (from-to)	920-924
Number of pages	5
Journal	Journal of Labelled Compounds and Radiopharmaceuticals
Volume	62
Issue number	14
DOIs	https://doi.org/10.1002/jlcr.3796
Publication status	Published - 1 Dec 2019

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

3-(benzylidene)indolin-2-one
isotope label
synthesis
α-synuclein

Access to Document

10.1002/jlcr.3796

Cite this

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title = "Synthesis of [13C2, 15N]-1,3-2H-1-benzyl-(Z)-3-(benzylidene)indolin-2-one",

abstract = "Parkinson disease (PD) is a neurodegenerative disorder characterized by the accumulation of α-synuclein into Lewy bodies. 3-Benzylidine-indolin-2-one represents a class of compounds, which are known to inhibit the accumulation of α-synuclein. In this paper, we report the synthesis of [13C] and [15N] labelled 1-benzyl-(Z)-3-(benzylidene)indolin-2-one from commercially available [13C2]-chloroacetic acid and [15N]-aniline in five steps. The product will be used to study its metabolites in human liver microsomes by liquid chromatography-tandem mass spectrometry.",

keywords = "3-(benzylidene)indolin-2-one, isotope label, synthesis, α-synuclein",

author = "Jixia Yang and Gongzheng Zhang and Zhaoyang Wang and Zhanxiong Xiao and Hongliang Wen",

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doi = "10.1002/jlcr.3796",

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T1 - Synthesis of [13C2, 15N]-1,3-2H-1-benzyl-(Z)-3-(benzylidene)indolin-2-one

AU - Yang, Jixia

AU - Zhang, Gongzheng

AU - Wang, Zhaoyang

AU - Xiao, Zhanxiong

AU - Wen, Hongliang

PY - 2019/12/1

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AB - Parkinson disease (PD) is a neurodegenerative disorder characterized by the accumulation of α-synuclein into Lewy bodies. 3-Benzylidine-indolin-2-one represents a class of compounds, which are known to inhibit the accumulation of α-synuclein. In this paper, we report the synthesis of [13C] and [15N] labelled 1-benzyl-(Z)-3-(benzylidene)indolin-2-one from commercially available [13C2]-chloroacetic acid and [15N]-aniline in five steps. The product will be used to study its metabolites in human liver microsomes by liquid chromatography-tandem mass spectrometry.

KW - 3-(benzylidene)indolin-2-one

KW - isotope label

KW - synthesis

KW - α-synuclein

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