Synthesis of [13C2,                             15N]-1,3-2H-1-benzyl-(Z)-3-(benzylidene)indolin-2-one

Jixia Yang; Gongzheng Zhang; Zhaoyang Wang; Zhanxiong Xiao; Hongliang Wen

doi:10.1002/jlcr.3796

Synthesis of [¹³C_2, ¹⁵N]-1,3-2H-1-benzyl-(Z)-3-(benzylidene)indolin-2-one

Jixia Yang, Gongzheng Zhang, Zhaoyang Wang, Zhanxiong Xiao, Hongliang Wen^*

^*Corresponding author for this work

School of Chemistry and Chemical Engineering

Beijing Institute of Technology

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Parkinson disease (PD) is a neurodegenerative disorder characterized by the accumulation of α-synuclein into Lewy bodies. 3-Benzylidine-indolin-2-one represents a class of compounds, which are known to inhibit the accumulation of α-synuclein. In this paper, we report the synthesis of [¹³C] and [¹⁵N] labelled 1-benzyl-(Z)-3-(benzylidene)indolin-2-one from commercially available [¹³C₂]-chloroacetic acid and [¹⁵N]-aniline in five steps. The product will be used to study its metabolites in human liver microsomes by liquid chromatography-tandem mass spectrometry.

Original language	English
Pages (from-to)	920-924
Number of pages	5
Journal	Journal of Labelled Compounds and Radiopharmaceuticals
Volume	62
Issue number	14
DOIs	https://doi.org/10.1002/jlcr.3796
Publication status	Published - 1 Dec 2019

Keywords

3-(benzylidene)indolin-2-one
isotope label
synthesis
α-synuclein

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1002/jlcr.3796

Cite this

@article{70e596201dbe454fb781db50ee18fca2,

title = "Synthesis of [13C2, 15N]-1,3-2H-1-benzyl-(Z)-3-(benzylidene)indolin-2-one",

abstract = "Parkinson disease (PD) is a neurodegenerative disorder characterized by the accumulation of α-synuclein into Lewy bodies. 3-Benzylidine-indolin-2-one represents a class of compounds, which are known to inhibit the accumulation of α-synuclein. In this paper, we report the synthesis of [13C] and [15N] labelled 1-benzyl-(Z)-3-(benzylidene)indolin-2-one from commercially available [13C2]-chloroacetic acid and [15N]-aniline in five steps. The product will be used to study its metabolites in human liver microsomes by liquid chromatography-tandem mass spectrometry.",

keywords = "3-(benzylidene)indolin-2-one, isotope label, synthesis, α-synuclein",

author = "Jixia Yang and Gongzheng Zhang and Zhaoyang Wang and Zhanxiong Xiao and Hongliang Wen",

note = "Publisher Copyright: {\textcopyright} 2019 John Wiley \& Sons, Ltd.",

year = "2019",

month = dec,

day = "1",

doi = "10.1002/jlcr.3796",

language = "English",

volume = "62",

pages = "920--924",

journal = "Journal of Labelled Compounds and Radiopharmaceuticals",

issn = "0362-4803",

publisher = "John Wiley and Sons Ltd",

number = "14",

}

TY - JOUR

T1 - Synthesis of [13C2, 15N]-1,3-2H-1-benzyl-(Z)-3-(benzylidene)indolin-2-one

AU - Yang, Jixia

AU - Zhang, Gongzheng

AU - Wang, Zhaoyang

AU - Xiao, Zhanxiong

AU - Wen, Hongliang

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Parkinson disease (PD) is a neurodegenerative disorder characterized by the accumulation of α-synuclein into Lewy bodies. 3-Benzylidine-indolin-2-one represents a class of compounds, which are known to inhibit the accumulation of α-synuclein. In this paper, we report the synthesis of [13C] and [15N] labelled 1-benzyl-(Z)-3-(benzylidene)indolin-2-one from commercially available [13C2]-chloroacetic acid and [15N]-aniline in five steps. The product will be used to study its metabolites in human liver microsomes by liquid chromatography-tandem mass spectrometry.

AB - Parkinson disease (PD) is a neurodegenerative disorder characterized by the accumulation of α-synuclein into Lewy bodies. 3-Benzylidine-indolin-2-one represents a class of compounds, which are known to inhibit the accumulation of α-synuclein. In this paper, we report the synthesis of [13C] and [15N] labelled 1-benzyl-(Z)-3-(benzylidene)indolin-2-one from commercially available [13C2]-chloroacetic acid and [15N]-aniline in five steps. The product will be used to study its metabolites in human liver microsomes by liquid chromatography-tandem mass spectrometry.

KW - 3-(benzylidene)indolin-2-one

KW - isotope label

KW - synthesis

KW - α-synuclein

UR - https://www.scopus.com/pages/publications/85075721451

U2 - 10.1002/jlcr.3796

DO - 10.1002/jlcr.3796

M3 - Article

C2 - 31379027

AN - SCOPUS:85075721451

SN - 0362-4803

VL - 62

SP - 920

EP - 924

JO - Journal of Labelled Compounds and Radiopharmaceuticals

JF - Journal of Labelled Compounds and Radiopharmaceuticals

IS - 14

ER -