Synthesis of limettin

Si Ping Pang; Lin Wang

Synthesis of limettin

Si Ping Pang^*, Lin Wang

^*Corresponding author for this work

School of Material Science and Engineering

Chinese People's Liberation Army

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

The synthesis of limettin is studied. 5,7-dihydroxycoumarin was synthesized through phloroglucin and ethyl propionate by the catalysis of ZnCl₂, with a yield of 97.7%. 5,7-dihydroxycoumarin was reacted with methylation reagents giving limettin. The conditions of methylation reaction were studied in detail and the optimization conditions determined with a yield of 75.7%: dimethyl sulfate was used as the methylation reagent, while dimethyl sulfate and 30% NaOH solution was dropped in alternatively. The mechanism of methylation reaction is discussed.

Original language	English
Pages (from-to)	743-744+752
Journal	Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology
Volume	25
Issue number	8
Publication status	Published - Aug 2005

Keywords

Coumarin
Methylation
Synthesis

Cite this

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title = "Synthesis of limettin",

abstract = "The synthesis of limettin is studied. 5,7-dihydroxycoumarin was synthesized through phloroglucin and ethyl propionate by the catalysis of ZnCl2, with a yield of 97.7%. 5,7-dihydroxycoumarin was reacted with methylation reagents giving limettin. The conditions of methylation reaction were studied in detail and the optimization conditions determined with a yield of 75.7%: dimethyl sulfate was used as the methylation reagent, while dimethyl sulfate and 30% NaOH solution was dropped in alternatively. The mechanism of methylation reaction is discussed.",

keywords = "Coumarin, Methylation, Synthesis",

author = "Pang, {Si Ping} and Lin Wang",

year = "2005",

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T1 - Synthesis of limettin

AU - Pang, Si Ping

AU - Wang, Lin

PY - 2005/8

Y1 - 2005/8

N2 - The synthesis of limettin is studied. 5,7-dihydroxycoumarin was synthesized through phloroglucin and ethyl propionate by the catalysis of ZnCl2, with a yield of 97.7%. 5,7-dihydroxycoumarin was reacted with methylation reagents giving limettin. The conditions of methylation reaction were studied in detail and the optimization conditions determined with a yield of 75.7%: dimethyl sulfate was used as the methylation reagent, while dimethyl sulfate and 30% NaOH solution was dropped in alternatively. The mechanism of methylation reaction is discussed.

AB - The synthesis of limettin is studied. 5,7-dihydroxycoumarin was synthesized through phloroglucin and ethyl propionate by the catalysis of ZnCl2, with a yield of 97.7%. 5,7-dihydroxycoumarin was reacted with methylation reagents giving limettin. The conditions of methylation reaction were studied in detail and the optimization conditions determined with a yield of 75.7%: dimethyl sulfate was used as the methylation reagent, while dimethyl sulfate and 30% NaOH solution was dropped in alternatively. The mechanism of methylation reaction is discussed.

KW - Coumarin

KW - Methylation

KW - Synthesis

UR - http://www.scopus.com/inward/record.url?scp=26644468853&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:26644468853

SN - 1001-0645

VL - 25

SP - 743-744+752

JO - Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology

JF - Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology

IS - 8

ER -

Synthesis of limettin

Abstract

Keywords

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