Synthesis of 3-OH-6-O-methylerythro-mycin by one-step process

Tao Meng; Guo Wei Yao; Min Ma; Jian Hua Liang; Xin Lin Yang

Synthesis of 3-OH-6-O-methylerythro-mycin by one-step process

Tao Meng^*, Guo Wei Yao, Min Ma, Jian Hua Liang, Xin Lin Yang

^*Corresponding author for this work

School of Chemistry and Chemical Engineering

Beijing Institute of Technology

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

3-OH-6-O-methylerythromycin was prepared from 2′,4″-O-bis(trimethylsilyl)-6-O-methylerythromycin A 9-O-(l-ethoxycyclohexyl) oxime. Five reactions were operated in one step, including desilylation of 2′-trimethylsilyl, desilylation of 4″-trimethylsilyl, deetherification of 9-O-(1-ethoxycyclohexyl), deoximation and hydrolysis of cladinose, with an overall yield of 88%.

Original language	English
Pages (from-to)	195-197
Number of pages	3
Journal	Xiandai Huagong/Modern Chemical Industry
Volume	26
Issue number	SUPPL. 2
Publication status	Published - Oct 2006

Keywords

2′,4″-O-bis(trimethylsilyl)-6-O-methylerythromycin A 9-O-(1-ethoxycyclohexyl) oxime
3-OH-6-O-methylerythromycin
Clathromycin

Cite this

@article{f7cb39244c6840d3b24637bc4b6344a7,

title = "Synthesis of 3-OH-6-O-methylerythro-mycin by one-step process",

abstract = "3-OH-6-O-methylerythromycin was prepared from 2′,4″-O-bis(trimethylsilyl)-6-O-methylerythromycin A 9-O-(l-ethoxycyclohexyl) oxime. Five reactions were operated in one step, including desilylation of 2′-trimethylsilyl, desilylation of 4″-trimethylsilyl, deetherification of 9-O-(1-ethoxycyclohexyl), deoximation and hydrolysis of cladinose, with an overall yield of 88\%.",

keywords = "2′,4″-O-bis(trimethylsilyl)-6-O-methylerythromycin A 9-O-(1-ethoxycyclohexyl) oxime, 3-OH-6-O-methylerythromycin, Clathromycin",

author = "Tao Meng and Yao, \{Guo Wei\} and Min Ma and Liang, \{Jian Hua\} and Yang, \{Xin Lin\}",

year = "2006",

month = oct,

language = "English",

volume = "26",

pages = "195--197",

journal = "Xiandai Huagong/Modern Chemical Industry",

issn = "0253-4320",

publisher = "China National Chemical Information Center",

number = "SUPPL. 2",

}

TY - JOUR

T1 - Synthesis of 3-OH-6-O-methylerythro-mycin by one-step process

AU - Meng, Tao

AU - Yao, Guo Wei

AU - Ma, Min

AU - Liang, Jian Hua

AU - Yang, Xin Lin

PY - 2006/10

Y1 - 2006/10

N2 - 3-OH-6-O-methylerythromycin was prepared from 2′,4″-O-bis(trimethylsilyl)-6-O-methylerythromycin A 9-O-(l-ethoxycyclohexyl) oxime. Five reactions were operated in one step, including desilylation of 2′-trimethylsilyl, desilylation of 4″-trimethylsilyl, deetherification of 9-O-(1-ethoxycyclohexyl), deoximation and hydrolysis of cladinose, with an overall yield of 88%.

AB - 3-OH-6-O-methylerythromycin was prepared from 2′,4″-O-bis(trimethylsilyl)-6-O-methylerythromycin A 9-O-(l-ethoxycyclohexyl) oxime. Five reactions were operated in one step, including desilylation of 2′-trimethylsilyl, desilylation of 4″-trimethylsilyl, deetherification of 9-O-(1-ethoxycyclohexyl), deoximation and hydrolysis of cladinose, with an overall yield of 88%.

KW - 2′,4″-O-bis(trimethylsilyl)-6-O-methylerythromycin A 9-O-(1-ethoxycyclohexyl) oxime

KW - 3-OH-6-O-methylerythromycin

KW - Clathromycin

UR - http://www.scopus.com/inward/record.url?scp=33846104332&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:33846104332

SN - 0253-4320

VL - 26

SP - 195

EP - 197

JO - Xiandai Huagong/Modern Chemical Industry

JF - Xiandai Huagong/Modern Chemical Industry

IS - SUPPL. 2

ER -

Synthesis of 3-OH-6-O-methylerythro-mycin by one-step process

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