Abstract
3-OH-6-O-methylerythromycin was prepared from 2′,4″-O-bis(trimethylsilyl)-6-O-methylerythromycin A 9-O-(l-ethoxycyclohexyl) oxime. Five reactions were operated in one step, including desilylation of 2′-trimethylsilyl, desilylation of 4″-trimethylsilyl, deetherification of 9-O-(1-ethoxycyclohexyl), deoximation and hydrolysis of cladinose, with an overall yield of 88%.
Original language | English |
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Pages (from-to) | 195-197 |
Number of pages | 3 |
Journal | Xiandai Huagong/Modern Chemical Industry |
Volume | 26 |
Issue number | SUPPL. 2 |
Publication status | Published - Oct 2006 |
Keywords
- 2′,4″-O-bis(trimethylsilyl)-6-O-methylerythromycin A 9-O-(1-ethoxycyclohexyl) oxime
- 3-OH-6-O-methylerythromycin
- Clathromycin