Synthesis of 3-OH-6-O-methylerythro-mycin by one-step process

Tao Meng*, Guo Wei Yao, Min Ma, Jian Hua Liang, Xin Lin Yang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

3-OH-6-O-methylerythromycin was prepared from 2′,4″-O-bis(trimethylsilyl)-6-O-methylerythromycin A 9-O-(l-ethoxycyclohexyl) oxime. Five reactions were operated in one step, including desilylation of 2′-trimethylsilyl, desilylation of 4″-trimethylsilyl, deetherification of 9-O-(1-ethoxycyclohexyl), deoximation and hydrolysis of cladinose, with an overall yield of 88%.

Original languageEnglish
Pages (from-to)195-197
Number of pages3
JournalXiandai Huagong/Modern Chemical Industry
Volume26
Issue numberSUPPL. 2
Publication statusPublished - Oct 2006

Keywords

  • 2′,4″-O-bis(trimethylsilyl)-6-O-methylerythromycin A 9-O-(1-ethoxycyclohexyl) oxime
  • 3-OH-6-O-methylerythromycin
  • Clathromycin

Fingerprint

Dive into the research topics of 'Synthesis of 3-OH-6-O-methylerythro-mycin by one-step process'. Together they form a unique fingerprint.

Cite this