Synthesis, characterization and crystal structures of fluoro-substituted aroylhydrazones with antimicrobial activity

Fu Ming Wang; Li Jie Li; Guo Wei Zang; Tong Tong Deng; Zhong Lu You

doi:10.17344/ACSI.2020.6051

Synthesis, characterization and crystal structures of fluoro-substituted aroylhydrazones with antimicrobial activity

Fu Ming Wang^*, Li Jie Li, Guo Wei Zang, Tong Tong Deng, Zhong Lu You

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

A series of five new fluoro-substituted aroylhydrazones were prepared and structurally characterized by elemental analysis, IR, UV-Vis and 1H NMR spectroscopy, as well as single crystal X-ray diffraction. The compounds were evaluated for their antibacterial (Bacillus subtilis, Staphylococcus aureus, Escherichia coli, and Pseudomonas fluorescence) and antifungal (Candida albicans and Aspergillus niger) activities by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) method. The biological assay indicated that the presence of the electron-withdrawing groups in the aroylhydrazones improved their antimicrobial activities.

Original language	English
Pages (from-to)	541-547
Number of pages	7
Journal	Acta Chimica Slovenica
Volume	63
Issue number	3
DOIs	https://doi.org/10.17344/ACSI.2020.6051
Publication status	Published - 2021
Externally published	Yes

Keywords

Antimicrobial activity
Aroylhydrazone
Organic synthesis
Single crystal X-ray diffraction

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10.17344/ACSI.2020.6051

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abstract = "A series of five new fluoro-substituted aroylhydrazones were prepared and structurally characterized by elemental analysis, IR, UV-Vis and 1H NMR spectroscopy, as well as single crystal X-ray diffraction. The compounds were evaluated for their antibacterial (Bacillus subtilis, Staphylococcus aureus, Escherichia coli, and Pseudomonas fluorescence) and antifungal (Candida albicans and Aspergillus niger) activities by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) method. The biological assay indicated that the presence of the electron-withdrawing groups in the aroylhydrazones improved their antimicrobial activities.",

keywords = "Antimicrobial activity, Aroylhydrazone, Organic synthesis, Single crystal X-ray diffraction",

author = "Wang, {Fu Ming} and Li, {Li Jie} and Zang, {Guo Wei} and Deng, {Tong Tong} and You, {Zhong Lu}",

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T1 - Synthesis, characterization and crystal structures of fluoro-substituted aroylhydrazones with antimicrobial activity

AU - Wang, Fu Ming

AU - Li, Li Jie

AU - Zang, Guo Wei

AU - Deng, Tong Tong

AU - You, Zhong Lu

PY - 2021

Y1 - 2021

N2 - A series of five new fluoro-substituted aroylhydrazones were prepared and structurally characterized by elemental analysis, IR, UV-Vis and 1H NMR spectroscopy, as well as single crystal X-ray diffraction. The compounds were evaluated for their antibacterial (Bacillus subtilis, Staphylococcus aureus, Escherichia coli, and Pseudomonas fluorescence) and antifungal (Candida albicans and Aspergillus niger) activities by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) method. The biological assay indicated that the presence of the electron-withdrawing groups in the aroylhydrazones improved their antimicrobial activities.

AB - A series of five new fluoro-substituted aroylhydrazones were prepared and structurally characterized by elemental analysis, IR, UV-Vis and 1H NMR spectroscopy, as well as single crystal X-ray diffraction. The compounds were evaluated for their antibacterial (Bacillus subtilis, Staphylococcus aureus, Escherichia coli, and Pseudomonas fluorescence) and antifungal (Candida albicans and Aspergillus niger) activities by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) method. The biological assay indicated that the presence of the electron-withdrawing groups in the aroylhydrazones improved their antimicrobial activities.

KW - Antimicrobial activity

KW - Aroylhydrazone

KW - Organic synthesis

KW - Single crystal X-ray diffraction

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DO - 10.17344/ACSI.2020.6051

M3 - Article

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AN - SCOPUS:85115205837

SN - 1318-0207

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JO - Acta Chimica Slovenica

JF - Acta Chimica Slovenica

IS - 3

ER -

Synthesis, characterization and crystal structures of fluoro-substituted aroylhydrazones with antimicrobial activity

Abstract

Keywords

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