Synthesis and Bioactivity of Novel Trisubstituted Triazole Nucleosides

Yi Ning Wen; Zhi Feng Zhang; Ning Ning Liu; Yu Hong Xiang; Zhuo Yong Zhang; Graciela Andrei; Robert Snoeck; Dominique Schols; Qing Shan Zhang; Qin Pei Wu

doi:10.1080/15257770.2015.1115523

Synthesis and Bioactivity of Novel Trisubstituted Triazole Nucleosides

Yi Ning Wen
, Zhi Feng Zhang
, Ning Ning Liu
, Yu Hong Xiang
, Zhuo Yong Zhang
, Graciela Andrei
, Robert Snoeck
, Dominique Schols
, Qing Shan Zhang
, Qin Pei Wu^*

^*Corresponding author for this work

School of Chemistry and Chemical Engineering

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

A series of novel trisubstituted 1,2,3-triazole purine nucleosides were efficiently synthesized via Huisgen 1,3-dipolar cycloaddition in good yields. Bioactivity against cytomegalovirus (CMV) and varicella-zoster virus (VZV) in human embryonic lung cell cultures was evaluated and all compounds show low antiviral activity.

Original language	English
Pages (from-to)	147-160
Number of pages	14
Journal	Nucleosides, Nucleotides and Nucleic Acids
Volume	35
Issue number	3
DOIs	https://doi.org/10.1080/15257770.2015.1115523
Publication status	Published - 3 Mar 2016

Keywords

Huisgen 1,3,g-dipolar cycloaddition
antiviral
nucleosides
triazole

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10.1080/15257770.2015.1115523

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title = "Synthesis and Bioactivity of Novel Trisubstituted Triazole Nucleosides",

abstract = "A series of novel trisubstituted 1,2,3-triazole purine nucleosides were efficiently synthesized via Huisgen 1,3-dipolar cycloaddition in good yields. Bioactivity against cytomegalovirus (CMV) and varicella-zoster virus (VZV) in human embryonic lung cell cultures was evaluated and all compounds show low antiviral activity.",

keywords = "Huisgen 1,3,g-dipolar cycloaddition, antiviral, nucleosides, triazole",

author = "Wen, \{Yi Ning\} and Zhang, \{Zhi Feng\} and Liu, \{Ning Ning\} and Xiang, \{Yu Hong\} and Zhang, \{Zhuo Yong\} and Graciela Andrei and Robert Snoeck and Dominique Schols and Zhang, \{Qing Shan\} and Wu, \{Qin Pei\}",

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doi = "10.1080/15257770.2015.1115523",

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T1 - Synthesis and Bioactivity of Novel Trisubstituted Triazole Nucleosides

AU - Wen, Yi Ning

AU - Zhang, Zhi Feng

AU - Liu, Ning Ning

AU - Xiang, Yu Hong

AU - Zhang, Zhuo Yong

AU - Andrei, Graciela

AU - Snoeck, Robert

AU - Schols, Dominique

AU - Zhang, Qing Shan

AU - Wu, Qin Pei

PY - 2016/3/3

Y1 - 2016/3/3

N2 - A series of novel trisubstituted 1,2,3-triazole purine nucleosides were efficiently synthesized via Huisgen 1,3-dipolar cycloaddition in good yields. Bioactivity against cytomegalovirus (CMV) and varicella-zoster virus (VZV) in human embryonic lung cell cultures was evaluated and all compounds show low antiviral activity.

AB - A series of novel trisubstituted 1,2,3-triazole purine nucleosides were efficiently synthesized via Huisgen 1,3-dipolar cycloaddition in good yields. Bioactivity against cytomegalovirus (CMV) and varicella-zoster virus (VZV) in human embryonic lung cell cultures was evaluated and all compounds show low antiviral activity.

KW - Huisgen 1,3,g-dipolar cycloaddition

KW - antiviral

KW - nucleosides

KW - triazole

UR - https://www.scopus.com/pages/publications/84960465171

U2 - 10.1080/15257770.2015.1115523

DO - 10.1080/15257770.2015.1115523

M3 - Article

C2 - 26854981

AN - SCOPUS:84960465171

SN - 1525-7770

VL - 35

SP - 147

EP - 160

JO - Nucleosides, Nucleotides and Nucleic Acids

JF - Nucleosides, Nucleotides and Nucleic Acids

IS - 3

ER -

Synthesis and Bioactivity of Novel Trisubstituted Triazole Nucleosides

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Keywords

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