Synthesis and Adsorption Property of Hydrophilic Uridine Molecularly Imprinted Polymers

Hydrophilic uridine molecularly imprinted core-shell structured polymers (MIPs) were prepared via the distillation precipitation polymerization method using uridine, methyl methacrylate, ethylene glycol dimethacrylate, and 2, 2-azobisisobutyronitrile as the template molecule, functional monomer, cross-linker, and initiator, respectively. The adsorption kinetic behavior, equilibrium, and selectivity of uridine onto the MIPs were investigated by conducting a series of batch adsorption experiments. The results showed that the pseudo-first-order kinetic model provided a good correlation for the adsorption of uridine onto MIPs. The linear correlation coefficient R ² was 0.9884. The Langmuir and Freundlich modeling of the adsorption showed that the adsorption of the imprinted molecule uridine onto MIPs was fitted well to the Freundlich equation. The R ² value was 0.980. The separation capability of the MIPs to uridine and its analog was evaluated as HPLC column filling. The MIPs chromatographic column has a selectively distinguishing ability for uridine and its analog.