Switchable probes: PH-triggered and VEGFR2 targeted peptides screening through imprinting microarray

Yixia Qian; Weizhi Wang; Zihua Wang; Qiuju Han; Xiangqian Jia; Shu Yang; Zhiyuan Hu

doi:10.1039/c6cc01302c

Switchable probes: PH-triggered and VEGFR2 targeted peptides screening through imprinting microarray

Yixia Qian
, Weizhi Wang^*
, Zihua Wang
, Qiuju Han
, Xiangqian Jia
, Shu Yang
, Zhiyuan Hu

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

One switchable affinity peptide, STP, is screened out from a high-throughput library by an integrated imprinting microarray. STP is pH triggered and also the ligand of the marker VEGFR2. Efficient cell recognition and penetration as well as an in vivo image could be "turned on" and accelerated only in the condition of VEGFR2 overexpression and a mild acidic environment.

Original language	English
Pages (from-to)	5690-5693
Number of pages	4
Journal	Chemical Communications
Volume	52
Issue number	33
DOIs	https://doi.org/10.1039/c6cc01302c
Publication status	Published - 28 Apr 2016
Externally published	Yes

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10.1039/c6cc01302c

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title = "Switchable probes: PH-triggered and VEGFR2 targeted peptides screening through imprinting microarray",

abstract = "One switchable affinity peptide, STP, is screened out from a high-throughput library by an integrated imprinting microarray. STP is pH triggered and also the ligand of the marker VEGFR2. Efficient cell recognition and penetration as well as an in vivo image could be {"}turned on{"} and accelerated only in the condition of VEGFR2 overexpression and a mild acidic environment.",

author = "Yixia Qian and Weizhi Wang and Zihua Wang and Qiuju Han and Xiangqian Jia and Shu Yang and Zhiyuan Hu",

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T2 - PH-triggered and VEGFR2 targeted peptides screening through imprinting microarray

AU - Qian, Yixia

AU - Wang, Weizhi

AU - Wang, Zihua

AU - Han, Qiuju

AU - Jia, Xiangqian

AU - Yang, Shu

AU - Hu, Zhiyuan

PY - 2016/4/28

Y1 - 2016/4/28

N2 - One switchable affinity peptide, STP, is screened out from a high-throughput library by an integrated imprinting microarray. STP is pH triggered and also the ligand of the marker VEGFR2. Efficient cell recognition and penetration as well as an in vivo image could be "turned on" and accelerated only in the condition of VEGFR2 overexpression and a mild acidic environment.

AB - One switchable affinity peptide, STP, is screened out from a high-throughput library by an integrated imprinting microarray. STP is pH triggered and also the ligand of the marker VEGFR2. Efficient cell recognition and penetration as well as an in vivo image could be "turned on" and accelerated only in the condition of VEGFR2 overexpression and a mild acidic environment.

UR - https://www.scopus.com/pages/publications/84965053754

U2 - 10.1039/c6cc01302c

DO - 10.1039/c6cc01302c

M3 - Article

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AN - SCOPUS:84965053754

SN - 1359-7345

VL - 52

SP - 5690

EP - 5693

JO - Chemical Communications

JF - Chemical Communications

IS - 33

ER -

Switchable probes: PH-triggered and VEGFR2 targeted peptides screening through imprinting microarray

Abstract

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